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dc.contributor.authorWang, Jingen_US
dc.contributor.authorLi, Yaruen_US
dc.contributor.authorHan, Xuen_US
dc.contributor.authorHu, Huaen_US
dc.contributor.authorWang, Feien_US
dc.contributor.authorLi, Xiulouen_US
dc.contributor.authorYang, Kunen_US
dc.contributor.authorYuan, Jingen_US
dc.contributor.authorYao, Pingen_US
dc.contributor.authorMiao, Xiaopingen_US
dc.contributor.authorWei, Shengen_US
dc.contributor.authorWang, Youjieen_US
dc.contributor.authorCheng, Weihongen_US
dc.contributor.authorLiang, Yuanen_US
dc.contributor.authorZhang, Xiaominen_US
dc.contributor.authorGuo, Huanen_US
dc.contributor.authorYang, Handongen_US
dc.contributor.authorYuan, Jianminen_US
dc.contributor.authorKoh, Woon-Puayen_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorWu, Tangchunen_US
dc.contributor.authorPan, Anen_US
dc.contributor.authorHe, Meianen_US
dc.date.accessioned2017-03-28T23:52:34Z
dc.date.issued2017en_US
dc.identifier.citationWang, J., Y. Li, X. Han, H. Hu, F. Wang, X. Li, K. Yang, et al. 2017. “Serum bilirubin levels and risk of type 2 diabetes: results from two independent cohorts in middle-aged and elderly Chinese.” Scientific Reports 7 (1): 41338. doi:10.1038/srep41338. http://dx.doi.org/10.1038/srep41338.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:31731891
dc.description.abstractSerum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly remains unclear. We investigated both cross-sectional and prospective associations between serum bilirubin levels and T2D risk in the Dongfeng-Tongji (DFTJ) cohort, and replicated the prospective findings in a nested case-control study (509 cases and 509 controls) within the Singapore Chinese Health Study (SCHS). In the cross-sectional analysis of DFTJ cohort (15,575 participants with 2,532 diabetes cases), serum bilirubin levels (total, direct and indirect) increased in new on-set diabetes and decreased with the diabetic duration. In the longitudinal analysis of DFTJ cohort (772 incident diabetes cases during 4.5 years of follow-up among 12,530 diabetes-free participants at baseline), positive association was found between direct bilirubin and T2D risk comparing extreme quartiles, similar results were observed in the nested case-control study within SCHS. Total and indirect bilirubin levels were not significantly associated with T2D in either cohort. In conclusion, our findings do not support the protective association between serum bilirubin levels and incident T2D in the middle-aged and elderly adults; instead, direct bilirubin levels were associated with increased risk of T2D.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/srep41338en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292699/pdf/en
dash.licenseLAAen_US
dc.titleSerum bilirubin levels and risk of type 2 diabetes: results from two independent cohorts in middle-aged and elderly Chineseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorHu, Frank B.en_US
dc.date.available2017-03-28T23:52:34Z
dc.identifier.doi10.1038/srep41338*
dash.authorsorderedfalse
dash.contributor.affiliatedHu, Frank


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