dc.contributor.author | Fologea, Daniel | |
dc.contributor.author | Gershow, Marc | |
dc.contributor.author | Ledden, Bradley | |
dc.contributor.author | McNabb, David S. | |
dc.contributor.author | Golovchenko, Jene Andrew | |
dc.contributor.author | Li, Jiali | |
dc.date.accessioned | 2017-03-31T20:11:04Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Fologea, Daniel, Marc Gershow, Bradley Ledden, David S. McNabb, Jene A. Golovchenko, and Jiali Li. 2005. “Detecting Single Stranded DNA with a Solid State Nanopore.” Nano Lett. 5 (10) (October): 1905–1909. doi:10.1021/nl051199m. | en_US |
dc.identifier.issn | 1530-6984 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31887692 | |
dc.description.abstract | Voltage biased solid-state nanopores are used to detect and characterize individual single stranded DNA molecules of fixed micrometer length by operating a nanopore detector at pH values greater than ∼11.6. The distribution of observed molecular event durations and blockade currents shows that a significant fraction of the events obey a rule of constant event charge deficit (ecd) indicating that they correspond to molecules translocating through the nanopore in a distribution of folded and unfolded configurations. A surprisingly large component is unfolded. The result is an important milestone in developing solid-state nanopores for single molecule sequencing applications. | en_US |
dc.description.sponsorship | Engineering and Applied Sciences | en_US |
dc.description.sponsorship | Physics | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Chemical Society (ACS) | en_US |
dc.relation.isversionof | doi:10.1021/nl051199m | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543124/ | en_US |
dash.license | LAA | |
dc.title | Detecting Single Stranded DNA with a Solid State Nanopore | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Nano Letters | en_US |
dash.depositing.author | Golovchenko, Jene Andrew | |
dc.date.available | 2017-03-31T20:11:04Z | |
dc.identifier.doi | 10.1021/nl051199m | * |
dash.contributor.affiliated | Li, Jiali | |
dash.contributor.affiliated | Gershow, Marc | |
dash.contributor.affiliated | Golovchenko, Jene | |