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dc.contributor.authorGoff, Donald
dc.contributor.authorPizzagalli, Diego
dc.contributor.authorEvins, Anne
dc.contributor.authorGoff, Donald C.
dc.contributor.authorCulhane, Melissa A.
dc.contributor.authorBarr, Ruth S.
dc.date.accessioned2009-07-20T18:41:55Z
dc.date.issued2008
dc.identifier.citationBarr, Ruth S., Diego A. Pizzagalli, Melissa A. Culhane, Donald C. Goff, and Anne E. Evins. 2008. A single dose of nicotine enhances reward responsiveness in nonsmokers: Implications for development of dependence. Biological Psychiatry 63, no. 11: 1061-1065.en
dc.identifier.issn1873-2402en
dc.identifier.issn0006-3223en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:3196299
dc.description.abstractBackground: Tobacco smoking, driven by the addictive properties of nicotine, is the most prevalent preventable cause of death in the Western world. Accumulated evidence suggests that nicotine may increase appetitive responding for nondrug incentives in the environment. Methods: To test this hypothesis, we conducted a randomized, double-blind, placebo-controlled, crossover study of the effect of a single dose of transdermal nicotine on reward responsiveness in 30 psychiatrically healthy nonsmokers. A novel signal detection task in which correct responses were differentially rewarded in a 3:1 ratio was used to assess the extent to which participants modulated their behavior as a function of reward. Results: Despite expected adverse effects such as nausea, nicotine significantly increased response bias toward the more frequently rewarded condition, at the expense of accuracy, independent of effects on attention or overall vigilance. Additionally, response bias on placebo was greater in participants who received nicotine in the first session, indicating that an effect of nicotine on reward responsiveness or reward-based learning persisted for at least 1 week. Conclusions: These findings suggest that a single dose of nicotine enhances response to non-drug-related rewards in the environment, with lasting effects. This effect may contribute to reinforcement of early smoking behavior and development of nicotine dependence.en
dc.description.sponsorshipPsychologyen
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.biopsych.2007.09.015en
dash.licenseOAP
dc.subjectdrug addictionen
dc.subjectnon-smokersen
dc.subjectanhedoniaen
dc.subjectreward responsivenessen
dc.subjectnicotineen
dc.subjectrewarden
dc.titleA Single Dose of Nicotine Enhances Reward Responsiveness in Nonsmokers: Implications for Development of Dependenceen
dc.relation.journalBiological Psychiatryen
dash.depositing.authorPizzagalli, Diego
dc.identifier.doi10.1016/j.biopsych.2007.09.015*
dash.authorsorderedfalse
dash.contributor.affiliatedGoff, Donald
dash.contributor.affiliatedEvins, A
dash.contributor.affiliatedPizzagalli, Diego


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