dc.contributor.author | Bogdan, Ryan | |
dc.contributor.author | Pizzagalli, Diego | |
dc.date.accessioned | 2009-07-29T13:22:18Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Bogdan, Ryan, and Diego A. Pizzagalli. 2006. Acute stress reduces reward responsiveness: Implications for depression. Biological Psychiatry 60(10): 1147-1154. | en |
dc.identifier.issn | 0006-3223 | en |
dc.identifier.issn | 1873-2402 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:3200669 | |
dc.description.abstract | Background: Stress, one of the strongest risk factors for depression, has been linked to "anbedonic" behavior and dysfunctional reward-related neural circuitry in preclinical models. Methods: To test if acute stress reduces reward responsiveness (i.e., the ability to modulate behavior as a function of past reward), a signal-detection task coupled with a differential reinforcement schedule was utilized. Eighty female participants completed the task under both a stress condition, either threat-of-shock (h = 38) or negative performance feedback (h = 42), and a no-stress condition. Results: Stress increased negative affect and anxiety. As hypothesized based on preclinical findings, stress, particularly the threat-of-shock condition, impaired reward responsiveness. Regression analyses indicate that self-report measures of anbedonia predicted stress-induced hedonic deficits even after controlling for anxiety symptoms. Conclusions: These findings indicate that acute stress reduces reward responsiveness, particularly in individuals with anhedonic symptoms. Stress-induced hedonic deficit is a promising candidate mechanism linking stressful experiences to depression. | en |
dc.description.sponsorship | Psychology | en |
dc.language.iso | en_US | en |
dc.publisher | Elsevier | en |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.biopsych.2006.03.037 | en |
dash.license | LAA | |
dc.title | Acute Stress Reduces Reward Responsiveness: Implications for Depression | en |
dc.type | Journal Article | |
dc.description.version | Accepted Manuscript | |
dc.relation.journal | Biological Psychiatry | en |
dash.depositing.author | Pizzagalli, Diego | |
dc.identifier.doi | 10.1016/j.biopsych.2006.03.037 | * |
dash.contributor.affiliated | Bogdan, Ryan | |
dash.contributor.affiliated | Pizzagalli, Diego | |