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dc.contributor.authorFromer, Menachemen_US
dc.contributor.authorRoussos, Panosen_US
dc.contributor.authorSieberts, Solveig Ken_US
dc.contributor.authorJohnson, Jessica Sen_US
dc.contributor.authorKavanagh, David Hen_US
dc.contributor.authorPerumal, Thanneer Men_US
dc.contributor.authorRuderfer, Douglas Men_US
dc.contributor.authorOh, Edwin Cen_US
dc.contributor.authorTopol, Aaronen_US
dc.contributor.authorShah, Hardik Ren_US
dc.contributor.authorKlei, Lambertus Len_US
dc.contributor.authorKramer, Robinen_US
dc.contributor.authorPinto, Dalilaen_US
dc.contributor.authorGümüş, Zeynep Hen_US
dc.contributor.authorCicek, A. Ercumenten_US
dc.contributor.authorDang, Kristen Ken_US
dc.contributor.authorBrowne, Andrewen_US
dc.contributor.authorLu, Congen_US
dc.contributor.authorXie, Luen_US
dc.contributor.authorReadhead, Benen_US
dc.contributor.authorStahl, Eli Aen_US
dc.contributor.authorParvizi, Mahsaen_US
dc.contributor.authorHamamsy, Tymoren_US
dc.contributor.authorFullard, John Fen_US
dc.contributor.authorWang, Ying-Chihen_US
dc.contributor.authorMahajan, Milind Cen_US
dc.contributor.authorDerry, Jonathan M Jen_US
dc.contributor.authorDudley, Joelen_US
dc.contributor.authorHemby, Scott Een_US
dc.contributor.authorLogsdon, Benjamin Aen_US
dc.contributor.authorTalbot, Konraden_US
dc.contributor.authorRaj, Towfiqueen_US
dc.contributor.authorBennett, David Aen_US
dc.contributor.authorDe Jager, Philip Len_US
dc.contributor.authorZhu, Junen_US
dc.contributor.authorZhang, Binen_US
dc.contributor.authorSullivan, Patrick Fen_US
dc.contributor.authorChess, Andrewen_US
dc.contributor.authorPurcell, Shaun Men_US
dc.contributor.authorShinobu, Leslie Aen_US
dc.contributor.authorMangravite, Lara Men_US
dc.contributor.authorToyoshiba, Hiroyoshien_US
dc.contributor.authorGur, Raquel Een_US
dc.contributor.authorHahn, Chang-Gyuen_US
dc.contributor.authorLewis, David Aen_US
dc.contributor.authorHaroutunian, Vahramen_US
dc.contributor.authorPeters, Mette Aen_US
dc.contributor.authorLipska, Barbara Ken_US
dc.contributor.authorBuxbaum, Joseph Den_US
dc.contributor.authorSchadt, Eric Een_US
dc.contributor.authorHirai, Keisukeen_US
dc.contributor.authorRoeder, Kathrynen_US
dc.contributor.authorBrennand, Kristen Jen_US
dc.contributor.authorKatsanis, Nicholasen_US
dc.contributor.authorDomenici, Enricoen_US
dc.contributor.authorDevlin, Bernieen_US
dc.contributor.authorSklar, Pamelaen_US
dc.date.accessioned2017-04-06T03:18:10Z
dc.date.issued2016en_US
dc.identifier.citationFromer, M., P. Roussos, S. K. Sieberts, J. S. Johnson, D. H. Kavanagh, T. M. Perumal, D. M. Ruderfer, et al. 2016. “Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia.” Nature neuroscience 19 (11): 1442-1453. doi:10.1038/nn.4399. http://dx.doi.org/10.1038/nn.4399.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32071902
dc.description.abstractOver 100 genetic loci harbor schizophrenia associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of schizophrenia cases (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ~20% of schizophrenia loci have variants that could contribute to altered gene expression and liability. In five loci, only a single gene was involved: FURIN, TSNARE1, CNTN4, CLCN3, or SNAP91. Altering expression of FURIN, TSNARE1, or CNTN4 changes neurodevelopment in zebrafish; knockdown of FURIN in human neural progenitor cells yields abnormal migration. Of 693 genes showing significant case/control differential expression, their fold changes are ≤ 1.33, and an independent cohort yields similar results. Gene co-expression implicates a network relevant for schizophrenia. Our findings show schizophrenia is polygenic and highlight the utility of this resource for mechanistic interpretations of genetic liability for brain diseases.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nn.4399en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083142/pdf/en
dash.licenseLAAen_US
dc.subjectSchizophreniaen
dc.subjectdorsolateral prefrontal cortexen
dc.subjectpostmortem studyen
dc.subjectgene expressionen
dc.subjectRNA-seqen
dc.subjectcase-control studyen
dc.subjectbiomarkeren
dc.subjecteQTLen
dc.subjectfunctional GWASen
dc.subjectzebrafishen
dc.subjecthiPSCen
dc.titleGene Expression Elucidates Functional Impact of Polygenic Risk for Schizophreniaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature neuroscienceen
dash.depositing.authorDe Jager, Philip Len_US
dc.date.available2017-04-06T03:18:10Z
dc.identifier.doi10.1038/nn.4399*
dash.authorsorderedfalse
dash.contributor.affiliatedDe Jager, Philip


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