Neuropsychiatric symptoms in untreated Parkinson’s disease

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Neuropsychiatric symptoms in untreated Parkinson’s disease

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Title: Neuropsychiatric symptoms in untreated Parkinson’s disease
Author: Szatmari, Szabolcs; Illigens, Ben Min-Woo; Siepmann, Timo; Pinter, Alexandra; Takats, Annamaria; Bereczki, Daniel

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Citation: Szatmari, Szabolcs, Ben Min-Woo Illigens, Timo Siepmann, Alexandra Pinter, Annamaria Takats, and Daniel Bereczki. 2017. “Neuropsychiatric symptoms in untreated Parkinson’s disease.” Neuropsychiatric Disease and Treatment 13 (1): 815-826. doi:10.2147/NDT.S130997. http://dx.doi.org/10.2147/NDT.S130997.
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Abstract: Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease. Few studies report on NPS in the early, untreated phase of PD. We reviewed the current literature on NPS in PD with a focus on the early, drug-naive stages of PD. Among these early disease stages, premotor and early motor phases were separately addressed in our review, highlighting the underlying pathophysiological mechanisms as well as epidemiological characteristics, clinical features, risk factors, and available techniques of clinical assessment.
Published Version: doi:10.2147/NDT.S130997
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360401/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32071926
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