Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

DSpace/Manakin Repository

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

Citable link to this page

 

 
Title: Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation
Author: Fielding, Ceri A; Weekes, Michael P; Nobre, Luis V; Ruckova, Eva; Wilkie, Gavin S; Paulo, Joao A; Chang, Chiwen; Suárez, Nicolás M; Davies, James A; Antrobus, Robin; Stanton, Richard J; Aicheler, Rebecca J; Nichols, Hester; Vojtesek, Borek; Trowsdale, John; Davison, Andrew J; Gygi, Steven P; Tomasec, Peter; Lehner, Paul J; Wilkinson, Gavin W G

Note: Order does not necessarily reflect citation order of authors.

Citation: Fielding, C. A., M. P. Weekes, L. V. Nobre, E. Ruckova, G. S. Wilkie, J. A. Paulo, C. Chang, et al. 2017. “Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.” eLife 6 (1): e22206. doi:10.7554/eLife.22206. http://dx.doi.org/10.7554/eLife.22206.
Full Text & Related Files:
Abstract: The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation. DOI: http://dx.doi.org/10.7554/eLife.22206.001
Published Version: doi:10.7554/eLife.22206
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367895/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32071983
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters