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dc.contributor.authorHao, Xiaokeen_US
dc.contributor.authorLi, Chanxiuen_US
dc.contributor.authorDu, Leien_US
dc.contributor.authorYao, Xiaohuien_US
dc.contributor.authorYan, Jingwenen_US
dc.contributor.authorRisacher, Shannon L.en_US
dc.contributor.authorSaykin, Andrew J.en_US
dc.contributor.authorShen, Lien_US
dc.contributor.authorZhang, Daoqiangen_US
dc.contributor.authorWeiner, Michael W.en_US
dc.contributor.authorAisen, Paulen_US
dc.contributor.authorPetersen, Ronalden_US
dc.contributor.authorJack, Clifford R.en_US
dc.contributor.authorMason, Sara S.en_US
dc.contributor.authorAlbers, Colleen S.en_US
dc.contributor.authorKnopman, Daviden_US
dc.contributor.authorJohnson, Krisen_US
dc.contributor.authorJagust, Williamen_US
dc.contributor.authorTrojanowki, John Q.en_US
dc.contributor.authorToga, Arthur W.en_US
dc.contributor.authorBeckett, Laurelen_US
dc.contributor.authorGreen, Robert C.en_US
dc.contributor.authorFarlow, Martin R.en_US
dc.contributor.authorMarie Hake, Annen_US
dc.contributor.authorMatthews, Brandy R.en_US
dc.contributor.authorBrosch, Jared R.en_US
dc.contributor.authorHerring, Scotten_US
dc.contributor.authorHunt, Cynthiaen_US
dc.contributor.authorShaw, Leslie M.en_US
dc.contributor.authorAnces, Beauen_US
dc.contributor.authorMorris, John C.en_US
dc.contributor.authorCarroll, Mariaen_US
dc.contributor.authorCreech, Mary L.en_US
dc.contributor.authorFranklin, Erinen_US
dc.contributor.authorMintun, Mark A.en_US
dc.contributor.authorSchneider, Stacyen_US
dc.contributor.authorOliver, Angelaen_US
dc.contributor.authorKaye, Jeffreyen_US
dc.contributor.authorQuinn, Josephen_US
dc.contributor.authorSilbert, Lisaen_US
dc.contributor.authorLind, Bettyen_US
dc.contributor.authorCarter, Rainaen_US
dc.contributor.authorDolen, Saraen_US
dc.contributor.authorSchneider, Lon S.en_US
dc.contributor.authorPawluczyk, Soniaen_US
dc.contributor.authorBeccera, Mauricioen_US
dc.contributor.authorTeodoro, Libertyen_US
dc.contributor.authorSpann, Bryan M.en_US
dc.contributor.authorBrewer, Jamesen_US
dc.contributor.authorVanderswag, Helenen_US
dc.contributor.authorFleisher, Adamen_US
dc.contributor.authorTariot, Pierreen_US
dc.contributor.authorBurke, Annaen_US
dc.contributor.authorTrncic, Nadiraen_US
dc.contributor.authorReeder, Stephanieen_US
dc.contributor.authorHeidebrink, Judith L.en_US
dc.contributor.authorLord, Joanne L.en_US
dc.contributor.authorDoody, Rachelle S.en_US
dc.contributor.authorVillanueva-Meyer, Javieren_US
dc.contributor.authorChowdhury, Muniren_US
dc.contributor.authorRountree, Susanen_US
dc.contributor.authorDang, Mimien_US
dc.contributor.authorStern, Yaakoven_US
dc.contributor.authorHonig, Lawrence S.en_US
dc.contributor.authorBell, Karen L.en_US
dc.contributor.authorMarson, Danielen_US
dc.contributor.authorGriffith, Randallen_US
dc.contributor.authorClark, Daviden_US
dc.contributor.authorGeldmacher, Daviden_US
dc.contributor.authorBrockington, Johnen_US
dc.contributor.authorRoberson, Eriken_US
dc.contributor.authorLove, Marissa Natelsonen_US
dc.contributor.authorGrossman, Hillelen_US
dc.contributor.authorMitsis, Effieen_US
dc.contributor.authorShah, Raj C.en_US
dc.contributor.authordeToledo-Morrell, Leylaen_US
dc.contributor.authorDuara, Ranjanen_US
dc.contributor.authorVaron, Danielen_US
dc.contributor.authorGreig, Maria T.en_US
dc.contributor.authorRoberts, Peggyen_US
dc.contributor.authorAlbert, Marilynen_US
dc.contributor.authorOnyike, Chiadien_US
dc.contributor.authorD’Agostino, Danielen_US
dc.contributor.authorKielb, Stephanieen_US
dc.contributor.authorGalvin, James E.en_US
dc.contributor.authorCerbone, Brittanyen_US
dc.contributor.authorMichel, Christina A.en_US
dc.contributor.authorPogorelec, Dana M.en_US
dc.contributor.authorRusinek, Henryen_US
dc.contributor.authorde Leon, Mony J.en_US
dc.contributor.authorGlodzik, Lidiaen_US
dc.contributor.authorDe Santi, Susanen_US
dc.contributor.authorDoraiswamy, P. Muralien_US
dc.contributor.authorPetrella, Jeffrey R.en_US
dc.contributor.authorBorges-Neto, Salvadoren_US
dc.contributor.authorWong, Terence Z.en_US
dc.contributor.authorColeman, Edwarden_US
dc.contributor.authorSmith, Charles D.en_US
dc.contributor.authorJicha, Gregen_US
dc.contributor.authorHardy, Peteren_US
dc.contributor.authorSinha, Parthaen_US
dc.contributor.authorOates, Elizabethen_US
dc.contributor.authorConrad, Garyen_US
dc.contributor.authorPorsteinsson, Anton P.en_US
dc.contributor.authorGoldstein, Bonnie S.en_US
dc.contributor.authorMartin, Kimen_US
dc.contributor.authorMakino, Kelly M.en_US
dc.contributor.authorIsmail, M. Saleemen_US
dc.contributor.authorBrand, Connieen_US
dc.contributor.authorMulnard, Ruth A.en_US
dc.contributor.authorThai, Gabyen_US
dc.contributor.authorMc-Adams-Ortiz, Catherineen_US
dc.contributor.authorWomack, Kyleen_US
dc.contributor.authorMathews, Danaen_US
dc.contributor.authorQuiceno, Maryen_US
dc.contributor.authorLevey, Allan I.en_US
dc.contributor.authorLah, James J.en_US
dc.contributor.authorCellar, Janet S.en_US
dc.contributor.authorBurns, Jeffrey M.en_US
dc.contributor.authorSwerdlow, Russell H.en_US
dc.contributor.authorBrooks, William M.en_US
dc.contributor.authorApostolova, Lianaen_US
dc.contributor.authorTingus, Kathleenen_US
dc.contributor.authorWoo, Ellenen_US
dc.contributor.authorSilverman, Daniel H. S.en_US
dc.contributor.authorLu, Po H.en_US
dc.contributor.authorBartzokis, Georgeen_US
dc.contributor.authorGraff-Radford, Neill R.en_US
dc.contributor.authorParfitt, Francineen_US
dc.contributor.authorKendall, Tracyen_US
dc.contributor.authorJohnson, Heatheren_US
dc.contributor.authorvan Dyck, Christopher H.en_US
dc.contributor.authorCarson, Richard E.en_US
dc.contributor.authorMacAvoy, Martha G.en_US
dc.contributor.authorVarma, Pradeepen_US
dc.contributor.authorChertkow, Howarden_US
dc.contributor.authorBergman, Howarden_US
dc.contributor.authorHosein, Chrisen_US
dc.contributor.authorBlack, Sandraen_US
dc.contributor.authorStefanovic, Bojanaen_US
dc.contributor.authorCaldwell, Curtisen_US
dc.contributor.authorHsiung, Ging-Yuek Robinen_US
dc.contributor.authorFeldman, Howarden_US
dc.contributor.authorMudge, Benitaen_US
dc.contributor.authorAssaly, Micheleen_US
dc.contributor.authorFinger, Elizabethen_US
dc.contributor.authorPasternack, Stephenen_US
dc.contributor.authorRachisky, Irinaen_US
dc.contributor.authorTrost, Dicken_US
dc.contributor.authorKertesz, Andrewen_US
dc.contributor.authorBernick, Charlesen_US
dc.contributor.authorMunic, Donnaen_US
dc.contributor.authorMesulam, Marek-Marselen_US
dc.contributor.authorLipowski, Kristineen_US
dc.contributor.authorWeintraub, Sandraen_US
dc.contributor.authorBonakdarpour, Bornaen_US
dc.contributor.authorKerwin, Dianaen_US
dc.contributor.authorWu, Chuang-Kuoen_US
dc.contributor.authorJohnson, Nancyen_US
dc.contributor.authorSadowsky, Carlen_US
dc.contributor.authorVillena, Teresaen_US
dc.contributor.authorTurner, Raymond Scotten_US
dc.contributor.authorJohnson, Kathleenen_US
dc.contributor.authorReynolds, Brigiden_US
dc.contributor.authorSperling, Reisa A.en_US
dc.contributor.authorJohnson, Keith A.en_US
dc.contributor.authorMarshall, Gaden_US
dc.contributor.authorYesavage, Jeromeen_US
dc.contributor.authorTaylor, Joy L.en_US
dc.contributor.authorLane, Bartonen_US
dc.contributor.authorRosen, Allysonen_US
dc.contributor.authorTinklenberg, Jareden_US
dc.contributor.authorSabbagh, Marwan N.en_US
dc.contributor.authorBelden, Christine M.en_US
dc.contributor.authorJacobson, Sandra A.en_US
dc.contributor.authorSirrel, Sherye A.en_US
dc.contributor.authorKowall, Neilen_US
dc.contributor.authorKilliany, Ronalden_US
dc.contributor.authorBudson, Andrew E.en_US
dc.contributor.authorNorbash, Alexanderen_US
dc.contributor.authorJohnson, Patricia Lynnen_US
dc.contributor.authorObisesan, Thomas O.en_US
dc.contributor.authorWolday, Sabaen_US
dc.contributor.authorAllard, Joanneen_US
dc.contributor.authorLerner, Alanen_US
dc.contributor.authorOgrocki, Paulaen_US
dc.contributor.authorTatsuoka, Curtisen_US
dc.contributor.authorFatica, Parianneen_US
dc.contributor.authorFletcher, Evanen_US
dc.contributor.authorMaillard, Paulineen_US
dc.contributor.authorOlichney, Johnen_US
dc.contributor.authorDeCarli, Charlesen_US
dc.contributor.authorCarmichael, Owenen_US
dc.contributor.authorKittur, Smitaen_US
dc.contributor.authorBorrie, Michaelen_US
dc.contributor.authorLee, T.-Y.en_US
dc.contributor.authorBartha, Roben_US
dc.contributor.authorJohnson, Sterlingen_US
dc.contributor.authorAsthana, Sanjayen_US
dc.contributor.authorCarlsson, Cynthia M.en_US
dc.contributor.authorPotkin, Steven G.en_US
dc.contributor.authorPreda, Adrianen_US
dc.contributor.authorNguyen, Danaen_US
dc.contributor.authorBates, Verniceen_US
dc.contributor.authorCapote, Horacioen_US
dc.contributor.authorRainka, Michelleen_US
dc.contributor.authorScharre, Douglas W.en_US
dc.contributor.authorKataki, Mariaen_US
dc.contributor.authorAdeli, Anahitaen_US
dc.contributor.authorZimmerman, Earl A.en_US
dc.contributor.authorCelmins, Dzintraen_US
dc.contributor.authorBrown, Alice D.en_US
dc.contributor.authorPearlson, Godfrey D.en_US
dc.contributor.authorBlank, Karenen_US
dc.contributor.authorAnderson, Karenen_US
dc.contributor.authorFlashman, Laura A.en_US
dc.contributor.authorSeltzer, Marcen_US
dc.contributor.authorHynes, Mary L.en_US
dc.contributor.authorSantulli, Robert B.en_US
dc.contributor.authorSink, Kaycee M.en_US
dc.contributor.authorGordineer, Leslieen_US
dc.contributor.authorWilliamson, Jeff D.en_US
dc.contributor.authorGarg, Pradeepen_US
dc.contributor.authorWatkins, Franklinen_US
dc.contributor.authorOtt, Brian R.en_US
dc.contributor.authorQuerfurth, Henryen_US
dc.contributor.authorTremont, Geoffreyen_US
dc.contributor.authorSalloway, Stephenen_US
dc.contributor.authorMalloy, Paulen_US
dc.contributor.authorCorreia, Stephenen_US
dc.contributor.authorRosen, Howard J.en_US
dc.contributor.authorMiller, Bruce L.en_US
dc.contributor.authorPerry, Daviden_US
dc.contributor.authorMintzer, Jacoboen_US
dc.contributor.authorSpicer, Kennethen_US
dc.contributor.authorBachman, Daviden_US
dc.contributor.authorPomara, Nunzioen_US
dc.contributor.authorHernando, Raymundoen_US
dc.contributor.authorSarrael, Anteroen_US
dc.contributor.authorRelkin, Normanen_US
dc.contributor.authorChaing, Gloriaen_US
dc.contributor.authorLin, Michaelen_US
dc.contributor.authorRavdin, Lisaen_US
dc.contributor.authorSmith, Amandaen_US
dc.contributor.authorRaj, Balebail Ashoken_US
dc.contributor.authorFargher, Kristinen_US
dc.date.accessioned2017-04-06T03:18:50Z
dc.date.issued2017en_US
dc.identifier.citationHao, X., C. Li, L. Du, X. Yao, J. Yan, S. L. Risacher, A. J. Saykin, et al. 2017. “Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease.” Scientific Reports 7 (1): 44272. doi:10.1038/srep44272. http://dx.doi.org/10.1038/srep44272.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32071994
dc.description.abstractNeuroimaging genetics is an emerging field that aims to identify the associations between genetic variants (e.g., single nucleotide polymorphisms (SNPs)) and quantitative traits (QTs) such as brain imaging phenotypes. In recent studies, in order to detect complex multi-SNP-multi-QT associations, bi-multivariate techniques such as various structured sparse canonical correlation analysis (SCCA) algorithms have been proposed and used in imaging genetics studies. However, associations between genetic markers and imaging QTs identified by existing bi-multivariate methods may not be all disease specific. To bridge this gap, we propose an analytical framework, based on three-way sparse canonical correlation analysis (T-SCCA), to explore the intrinsic associations among genetic markers, imaging QTs, and clinical scores of interest. We perform an empirical study using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort to discover the relationships among SNPs from AD risk gene APOE, imaging QTs extracted from structural magnetic resonance imaging scans, and cognitive and diagnostic outcomes. The proposed T-SCCA model not only outperforms the traditional SCCA method in terms of identifying strong associations, but also discovers robust outcome-relevant imaging genetic patterns, demonstrating its promise for improving disease-related mechanistic understanding.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/srep44272en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349597/pdf/en
dash.licenseLAAen_US
dc.titleMining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Diseaseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorGreen, Robert C.en_US
dc.date.available2017-04-06T03:18:50Z
dc.identifier.doi10.1038/srep44272*
dash.authorsorderedfalse
dash.contributor.affiliatedGreen, Robert
dash.contributor.affiliatedMarshall, Gad
dash.contributor.affiliatedJohnson, Keith
dash.contributor.affiliatedSperling, Reisa


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