Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

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https://doi.org/10.1186/s40425-017-0230-9Metadata
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Scarfò, Irene, and Marcela V. Maus. 2017. “Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment.” Journal for Immunotherapy of Cancer 5 (1): 28. doi:10.1186/s40425-017-0230-9. http://dx.doi.org/10.1186/s40425-017-0230-9.Abstract
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359946/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072017
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