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dc.contributor.authorScarfò, Ireneen_US
dc.contributor.authorMaus, Marcela V.en_US
dc.date.accessioned2017-04-06T03:18:59Z
dc.date.issued2017en_US
dc.identifier.citationScarfò, Irene, and Marcela V. Maus. 2017. “Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment.” Journal for Immunotherapy of Cancer 5 (1): 28. doi:10.1186/s40425-017-0230-9. http://dx.doi.org/10.1186/s40425-017-0230-9.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32072017
dc.description.abstractChimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s40425-017-0230-9en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359946/pdf/en
dash.licenseLAAen_US
dc.subjectChimeric antigen receptor T-cellsen
dc.subjectAdoptive immunotherapyen
dc.subjectTumor microenvironmenten
dc.titleCurrent approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironmenten
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal for Immunotherapy of Canceren
dash.depositing.authorScarfò, Ireneen_US
dc.date.available2017-04-06T03:18:59Z
dc.identifier.doi10.1186/s40425-017-0230-9*
dash.contributor.affiliatedScarfo, Irene
dash.contributor.affiliatedMaus, Marcela


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