Porous microwells for geometry-selective, large-scale microparticle arrays

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Porous microwells for geometry-selective, large-scale microparticle arrays

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Title: Porous microwells for geometry-selective, large-scale microparticle arrays
Author: Kim, Jae Jung; Bong, Ki Wan; Reátegui, Eduardo; Irimia, Daniel; Doyle, Patrick S.

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Citation: Kim, Jae Jung, Ki Wan Bong, Eduardo Reátegui, Daniel Irimia, and Patrick S. Doyle. 2016. “Porous microwells for geometry-selective, large-scale microparticle arrays.” Nature materials 16 (1): 139-146. doi:10.1038/nmat4747. http://dx.doi.org/10.1038/nmat4747.
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Abstract: Large-scale microparticle arrays (LSMA) are key for material science and bioengineering applications. However, previous approaches suffer from tradeoffs between scalability, precision, specificity, and versatility. Here, we present a porous microwell-based approach to create large-scale microparticle arrays with complex motifs. Microparticles are guided to and pushed into microwells by fluid flow through small open pores at the bottom of the porous well arrays. A scaling theory allows for the rational design of LSMAs to sort and array particles based on their size, shape or modulus. Sequential particle assembly allows for proximal and nested particle arrangements, as well as particle recollection and pattern transfer. We demonstrate the capabilities of the approach by means of three applications: high-throughput single-cell arrays; microenvironment fabrication for neutrophil chemotaxis; and complex, covert tags by the transfer of an upconversion nanocrystal laden LSMA.
Published Version: doi:10.1038/nmat4747
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173431/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072018
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