A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
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Author
Mullarky, Edouard
Lairson, Luke L.
Cantley, Lewis C.
Lyssiotis, Costas A.
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https://doi.org/10.1080/23723556.2016.1164280Metadata
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Mullarky, Edouard, Luke L. Lairson, Lewis C. Cantley, and Costas A. Lyssiotis. 2016. “A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.” Molecular & Cellular Oncology 3 (4): e1164280. doi:10.1080/23723556.2016.1164280. http://dx.doi.org/10.1080/23723556.2016.1164280.Abstract
ABSTRACT Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast cancer cells.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972100/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072062
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