Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
Brown, J. R.
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CitationKasar, S., and J. R. Brown. 2016. “Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.” Molecular & Cellular Oncology 3 (4): e1157667. doi:10.1080/23723556.2016.1157667. http://dx.doi.org/10.1080/23723556.2016.1157667.
AbstractABSTRACT Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature—that operate at different times throughout CLL evolution.
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