Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia

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Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia

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Title: Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
Author: Kasar, S.; Brown, J. R.

Note: Order does not necessarily reflect citation order of authors.

Citation: Kasar, S., and J. R. Brown. 2016. “Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.” Molecular & Cellular Oncology 3 (4): e1157667. doi:10.1080/23723556.2016.1157667. http://dx.doi.org/10.1080/23723556.2016.1157667.
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Abstract: ABSTRACT Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature—that operate at different times throughout CLL evolution.
Published Version: doi:10.1080/23723556.2016.1157667
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972118/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072063
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