Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis

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Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis

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Title: Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis
Author: Chen, Xiqun; Feng, Danielle; Schwarzschild, Michael A.; Gao, Xiang

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Citation: Chen, Xiqun, Danielle Feng, Michael A. Schwarzschild, and Xiang Gao. 2017. “Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis.” Annals of Clinical and Translational Neurology 4 (3): 212-216. doi:10.1002/acn3.381. http://dx.doi.org/10.1002/acn3.381.
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Abstract: Abstract Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair‐associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta‐analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.
Published Version: doi:10.1002/acn3.381
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338132/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072087
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