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dc.contributor.authorChen, Xiqunen_US
dc.contributor.authorFeng, Danielleen_US
dc.contributor.authorSchwarzschild, Michael A.en_US
dc.contributor.authorGao, Xiangen_US
dc.date.accessioned2017-04-06T03:19:27Z
dc.date.issued2017en_US
dc.identifier.citationChen, Xiqun, Danielle Feng, Michael A. Schwarzschild, and Xiang Gao. 2017. “Red hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysis.” Annals of Clinical and Translational Neurology 4 (3): 212-216. doi:10.1002/acn3.381. http://dx.doi.org/10.1002/acn3.381.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32072087
dc.description.abstractAbstract Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair‐associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta‐analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.en
dc.language.isoen_USen
dc.publisherJohn Wiley and Sons Inc.en
dc.relation.isversionofdoi:10.1002/acn3.381en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338132/pdf/en
dash.licenseLAAen_US
dc.subjectBrief Communicationen
dc.titleRed hair, MC1R variants, and risk for Parkinson's disease – a meta‐analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalAnnals of Clinical and Translational Neurologyen
dash.depositing.authorChen, Xiqunen_US
dc.date.available2017-04-06T03:19:27Z
dc.identifier.doi10.1002/acn3.381*
dash.contributor.affiliatedChen, Xiqun
dash.contributor.affiliatedSchwarzschild, Michael


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