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dc.contributor.authorGootenberg, David B.en_US
dc.contributor.authorPaer, Jeffrey M.en_US
dc.contributor.authorLuevano, Jesus-Marioen_US
dc.contributor.authorKwon, Douglas S.en_US
dc.date.accessioned2017-04-06T03:19:39Z
dc.date.issued2017en_US
dc.identifier.citationGootenberg, David B., Jeffrey M. Paer, Jesus-Mario Luevano, and Douglas S. Kwon. 2017. “HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation.” Current Opinion in Infectious Diseases 30 (1): 31-43. doi:10.1097/QCO.0000000000000341. http://dx.doi.org/10.1097/QCO.0000000000000341.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32072106
dc.description.abstractPurpose of review Despite HIV therapy advances, average life expectancy in HIV-infected individuals on effective treatment is significantly decreased relative to uninfected persons, largely because of increased incidence of inflammation-related diseases, such as cardiovascular disease and renal dysfunction. The enteric microbial community could potentially cause this inflammation, as HIV-driven destruction of gastrointestinal CD4+ T cells may disturb the microbiota–mucosal immune system balance, disrupting the stable gut microbiome and leading to further deleterious host outcomes. Recent findings Varied enteric microbiome changes have been reported during HIV infection, but unifying patterns have emerged. Community diversity is decreased, similar to pathologies such as inflammatory bowel disease, obesity, and Clostridium difficile infection. Many taxa frequently enriched in HIV-infected individuals, such as Enterobacteriaceae and Erysipelotrichaceae, have pathogenic potential, whereas depleted taxa, such as Bacteroidaceae and Ruminococcaceae, are more linked with anti-inflammatory properties and maintenance of gut homeostasis. The gut viral community in HIV has been found to contain a greater abundance of pathogenesis-associated Adenoviridae and Anelloviridae. These bacterial and viral changes correlate with increased systemic inflammatory markers, such as serum sCD14, sCD163, and IL-6. Summary Enteric microbial community changes may contribute to chronic HIV pathogenesis, but more investigation is necessary, especially in the developing world population with the greatest HIV burden (Video, Supplemental Digital Content 1, which includes the authors’ summary of the importance of the work).en
dc.language.isoen_USen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.isversionofdoi:10.1097/QCO.0000000000000341en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325247/pdf/en
dash.licenseLAAen_US
dc.subjectdeveloping worlden
dc.subjectHIVen
dc.subjectentericen
dc.subjectmicrobiomeen
dc.subjectsystemic inflammationen
dc.subjectviromeen
dc.titleHIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCurrent Opinion in Infectious Diseasesen
dash.depositing.authorGootenberg, David B.en_US
dc.date.available2017-04-06T03:19:39Z
dc.identifier.doi10.1097/QCO.0000000000000341*
dash.contributor.affiliatedGootenberg, David
dash.contributor.affiliatedLuevano, Jesus-Mario
dash.contributor.affiliatedKwon, Douglas


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