Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation

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Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation

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Title: Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation
Author: Sutton, Amy Alexandra; Shirman, Tanya; Timonen, Jaakko; England, Grant Tyler; Kim, Philseok; Kolle, Mathias; Ferrante, Thomas Charles; Zarzar, Lauren; Strong, Elizabeth; Aizenberg, Joanna

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Citation: Sutton, Amy, Tanya Shirman, Jaakko V. I. Timonen, Grant T England, Philseok Kim, Mathias Kolle, Thomas Ferrante, Lauren D Zarzar, Elizabeth Strong, and Joanna Aizenberg. 2017. “Photothermally Triggered Actuation of Hybrid Materials as a New Platform for in Vitro Cell Manipulation.” Nature Communications 8 (March 13): 14700. doi:10.1038/ncomms14700.
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Abstract: Mechanical forces in the cell’s natural environment have a crucial impact on growth, differentiation and behavior. Few areas of biology can be understood without taking into account how both individual cells and cell networks sense and transduce physical stresses. However, the field is currently held back by the limitations of the available methods to apply physiologically relevant stress profiles on cells, particularly with sub-cellular resolution, in controlled in vitro experiments. Here we report a new type of active cell culture material that allows highly localized, directional, and reversible deformation of the cell growth substrate, with control at scales ranging from the entire surface to the subcellular, and response times on the order of seconds. These capabilities are not matched by any other method, and this versatile material has the potential to bridge the performance gap between the existing single cell micro-manipulation and 2D cell sheet mechanical stimulation techniques.
Published Version: 10.1038/ncomms14700
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32094141
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