Show simple item record

dc.contributor.authorDickerson, Bradford Clark
dc.contributor.authorFeczko, Eric
dc.contributor.authorAugustinack, Jean C.
dc.contributor.authorPacheco, Jenni
dc.contributor.authorMorris, John C.
dc.contributor.authorFischl, Bruce
dc.contributor.authorBuckner, Randy Lee
dc.date.accessioned2017-04-13T15:59:25Z
dc.date.issued2009
dc.identifier.citationDickerson, Bradford, C., Eric Feczko, Jean C. Augustinack, Jenni Pacheco, John C. Morris, Bruce Fischl, and Randy L. Buckner. 2009. Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area. Neurobiology of Aging 30, no. 3: 432-440.en_US
dc.identifier.issn1558-1497en_US
dc.identifier.issn0197-4580en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32116840
dc.description.abstractThe volume of parcellated conical regions is a composite measure related to both thickness and surface area. It is not clear whether volumetric decreases in medial temporal lobe (MTL) cortical regions in aging and Alzheimer's disease (AD) are due to thinning, loss of surface area, or both, nor is it clear whether aging and AD differ in their effects on these properties. Participants included 28 Younger Normals, 47 Older Normals, and 29 patients with mild AD. T1-weighted MRI data were analyzed using a novel semi-automated protocol (presented in a companion article) to delineate the boundaries of entorhinal (ERC), perirhinal (PRC), and posterior parahippocampal (PPHC) cortical regions and calculate their mean thickness, surface area, and volume. Compared to Younger Normals, Older Normals demonstrated moderately reduced ERC and PPHC volumes, which were due primarily to reduced surface area. In contrast. the expected AD-related reduction in ERC volume was produced by a large reduction in thickness with minimal additional effect (beyond that of aging) on surface area. PRC and PPHC also showed large AD-related reductions in thickness. Of all these MTL morphometric measures, ERC and PRC thinning were the best predictors of poorer episodic memory performance in AD. Although the volumes of MTL cortical regions may decrease with both aging and AD, thickness is relatively preserved in normal aging, while even in its mild clinical stage, AD is associated with a large degree of thinning of MTL cortex. These differential morphometric effects of aging and AD may reflect distinct biologic processes and ultimately may provide insights into the anatomic substrates of change in memory-related functions of MTL cortex.en_US
dc.description.sponsorshipPsychologyen_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.07.022en_US
dash.licenseMETA_ONLY
dc.subjectAgingen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectParahippocampal cortexen_US
dc.subjectPerirhinal cortexen_US
dc.subjectEntorhinal cortexen_US
dc.titleDifferential Effects of Aging and Alzheimer's Disease on Medial Temporal Lobe Cortical Thickness and Surface Areaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNeurobiology of Agingen_US
dash.depositing.authorBuckner, Randy Lee
dc.date.available2017-04-13T15:59:25Z
dc.identifier.doi10.1016/j.neurobiolaging.2007.07.022*
workflow.legacycommentsBuckner emailed 2016-04-13 AD Buckner emailed 2017-02-16 MM meta.darken_US
dash.contributor.affiliatedDickerson, Bradford
dash.contributor.affiliatedBuckner, Randy
dash.contributor.affiliatedFischl, Bruce


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record