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dc.contributor.authorSmith, Maurice A
dc.contributor.authorBrandt, Jason
dc.contributor.authorShadmehr, Reza
dc.date.accessioned2017-04-13T16:23:40Z
dc.date.issued2000
dc.identifier.citationSmith, Maurice A., Jason Brandt, and Reza Shadmehr. 2000. Motor disorder in Huntington's disease begins as a dysfunction in error feedback control. Nature 403(6769): 544-549.en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32116864
dc.description.abstractA steady progression of motor dysfunction takes place in Huntington's disease1 (HD). The origin of this disturbance with relation to the motor control process is not understood. Here we studied reaching movements in asymptomatic HD gene-carriers (AGCs) and subjects with manifest HD. We found that movement jerkiness, which characterizes the smoothness and efficiency of motion, was a sensitive indicator of presymptomatic HD progression. A large fraction of AGCs displayed elevated jerk even when more than seven years remained until predicted disease onset. Movement termination was disturbed much more than initiation and was highly variable from trial to trial. Analysis of this variability revealed that the sensitivity of end-movement jerk to subtle, self-generated early-movement errors was greater in HD subjects than in controls. Additionally, we found that HD corrective responses to externally-generated force pulses were greatly disturbed, indicating that HD subjects display aberrant responses to both external and self-generated errors. Because feedback corrections are driven by error and are delayed such that they predominantly affect movement termination, these findings suggest that a dysfunction in error correction characterizes the motor control deficit in early HD. This dysfunction may be observed years before clinical disease onset and grows worse as the disease progresses.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/35000576en_US
dc.relation.hasversionhttp://www.seas.harvard.edu/motorlab/Reprints/nature00.pdfen_US
dash.licenseMETA_ONLY
dc.titleMotor Disorder in Huntington's Disease Begins as a Dysfunction in Error Feedback Controlen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNatureen_US
dash.depositing.authorSmith, Maurice A
dash.embargo.until10000-01-01
dc.identifier.doi10.1038/35000576*
workflow.legacycommentsSmith emailed 04-13-2016 AD Smith emailed 2017-02-16 MM meta.darken_US
dash.contributor.affiliatedSmith, Maurice


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