Show simple item record

dc.contributor.authorNeilan, Tomas G
dc.contributor.authorShah, Ravi Vikram
dc.contributor.authorAbbasi, Siddique Akbar
dc.contributor.authorFarhad, Hoshang
dc.contributor.authorGroarke, John David
dc.contributor.authorDodson, John
dc.contributor.authorCoelho-Filho, Otavio
dc.contributor.authorMcMullan, Ciaran Joseph
dc.contributor.authorHeydari, Bobak
dc.contributor.authorMichaud, Gregory F.
dc.contributor.authorJohn, Roy Mattathu
dc.contributor.authorvan der Geest, Rob
dc.contributor.authorSteigner, Michael L.
dc.contributor.authorBlankstein, Ron
dc.contributor.authorJerosch-Herold, Michael
dc.contributor.authorKwong, Raymond Yan-Kit
dc.date.accessioned2017-04-25T18:36:03Z
dc.date.issued2013
dc.identifierQuick submit: 2017-03-29T15:01:43-0400
dc.identifier.citationNeilan, Tomas G., Ravi V. Shah, Siddique A. Abbasi, Hoshang Farhad, John D. Groarke, John A. Dodson, Otavio Coelho-Filho, et al. 2013. “The Incidence, Pattern, and Prognostic Value of Left Ventricular Myocardial Scar by Late Gadolinium Enhancement in Patients With Atrial Fibrillation.” Journal of the American College of Cardiology 62 (23) (December): 2205–2214. doi:10.1016/j.jacc.2013.07.067.en_US
dc.identifier.issn0735-1097en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32415190
dc.description.abstractObjectives We aimed to identify the frequency, pattern, and prognostic significance of left ventricular (LV) late gadolinium enhancement (LGE) in patients with atrial fibrillation (AF). Background There are limited data on the presence, pattern, and prognostic significance of LV myocardial fibrosis in patients with AF. Late gadolinium enhancement during cardiac magnetic resonance (CMR) is a marker for myocardial fibrosis. Methods We studied a consecutive group of 664 patients without known prior myocardial infarction being referred for radiofrequency ablation of AF. CMR was requested to assess pulmonary venous anatomy. Results Overall, 73% were male, with an average age of 56 years, and an ejection fraction of 55±10%. Left ventricular LGE was found in 88 patients (13%). The endpoint was all-cause mortality, and in this cohort we observed 68 deaths over a median follow-up period of 42 months. On univariable analysis, age (HR 1.05, CI 1.03–1.08, LRχ2 15.2, p=0.0001), diabetes (HR 2.39, CI 1.41–4.09, LRχ210.3, p=0.001), a history of heart failure (HR 1.78, CI 1.09–2.91, LRχ2 5.37, p=0.02), left atrial dimension (HR 1.04, CI 1.01–1.08, LRχ2 6.47, p=0.01), presence of LGE (HR 5.08, CI 3.08–8.36, LRχ2 28.8, p<0.0001), and LGE extent (HR 1.15, CI 1.10–1.21, LRχ2 35.6, p<0.0001) provided the strongest association with mortality. The mortality rate was 8.1% per patient-years in patients with LGE vs. 2.3% patients without LGE. In the best overall multivariable model for mortality, age and the extent of LGE were independent predictors of mortality. Indeed, each 1% increase in LGE associated with a 15% increased risk of death. Conclusions In patients with AF, LV LGE is a frequent finding and is a powerful predictor of mortality.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.jacc.2013.07.067en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908872/en_US
dash.licenseLAA
dc.subjectLate Gadolinium Enhancementen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectCardiac Magnetic Resonanceen_US
dc.titleThe Incidence, Pattern, and Prognostic Value of Left Ventricular Myocardial Scar by Late Gadolinium Enhancement in Patients With Atrial Fibrillationen_US
dc.typeJournal Articleen_US
dc.date.updated2017-03-29T19:01:41Z
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJournal of the American College of Cardiologyen_US
dash.depositing.authorSteigner, Michael L.
dc.date.available2013
dc.date.available2017-04-25T18:36:03Z
dc.identifier.doi10.1016/j.jacc.2013.07.067*
dash.authorsorderedfalse
dash.contributor.affiliatedMcMullan, Ciaran Joseph
dash.contributor.affiliatedMichaud, Gregory F.
dash.contributor.affiliatedJohn, Roy M.
dash.contributor.affiliatedDodson, John
dash.contributor.affiliatedGroarke, John
dash.contributor.affiliatedKwong, Raymond
dash.contributor.affiliatedSteigner, Michael
dash.contributor.affiliatedAbbasi, Siddique Akbar
dash.contributor.affiliatedHeydari, Bobak
dash.contributor.affiliatedBlankstein, Ron
dash.contributor.affiliatedJerosch-Herold, Michael
dash.contributor.affiliatedShah, Ravi
dash.contributor.affiliatedNeilan, Tomas


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record