Contrast inhomogeneity in CT angiography of the abdominal aortic aneurysm

DSpace/Manakin Repository

Contrast inhomogeneity in CT angiography of the abdominal aortic aneurysm

Citable link to this page


Title: Contrast inhomogeneity in CT angiography of the abdominal aortic aneurysm
Author: George, Elizabeth; Giannopoulos, Andreas A.; Aghayev, Ayaz; Rohatgi, Saurabh; Imanzadeh, Amir; Antoniadis, Antonios P.; Kumamaru, Kanako; Chatzizisis, Yiannis; Dunne, Ruth Mary; Steigner, Michael L.; Hanley, Michael; Gravereaux, Edwin Charles; Rybicki, Frank; Mitsouras, Dimitrios

Note: Order does not necessarily reflect citation order of authors.

Citation: George, Elizabeth, Andreas A. Giannopoulos, Ayaz Aghayev, Saurabh Rohatgi, Amir Imanzadeh, Antonios P. Antoniadis, Kanako K. Kumamaru, et al. 2016. “Contrast Inhomogeneity in CT Angiography of the Abdominal Aortic Aneurysm.” Journal of Cardiovascular Computed Tomography 10 (2) (March): 179–183. doi:10.1016/j.jcct.2015.11.006.
Full Text & Related Files:
Abstract: Background

If undetected, infrarenal Abdominal Aortic Aneurysm (AAA) growth can lead to rupture, a high-mortality complication. Some AAA patients exhibit inhomogeneous luminal contrast attenuation at first-pass CT angiography (CTA). This study assesses the association between this observation and aneurysm growth.


Sixty-seven consecutive pre-repair AAA CTAs were included in this retrospective study. The “Gravitational Gradient” (GG), defined as the ratio of the mean attenuation in a region-of-interest placed posteriorly to that in a region-of-interest placed anteriorly within the lumen of the aortic aneurysm on a single axial slice, and the maximum aneurysm diameter were measured from each CT data set. “AAA Contrast Inhomogeneity” was defined as the absolute value of the difference between the GG and 1.0. Univariate and multivariate logistic regression was used to assess the association of aneurysm growth >0.4 and >1.0 cm/year to AAA Contrast Inhomogeneity, aneurysm diameter, patient characteristics and cardiovascular co-morbidities.


AAA Contrast Inhomogeneity was not correlated to aneurysm diameter (p=0.325). In multivariable analysis that included initial aneurysm diameter and AAA Contrast Inhomogeneity, both factors were significantly associated with rapid aneurysm growth (initial diameter: p=0.0029 and 0.011, and, AAA Contrast Inhomogeneity: p=0.045 and 0.048 for growth >0.4 cm/year and >1 cm/year respectively).


AAA Contrast Inhomogeneity is a common observation in first-pass CTA. It is associated with rapid aneurysm growth, independent of and incremental to aneurysm diameter.
Published Version: 10.1016/j.jcct.2015.11.006
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search