Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants

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Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants

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Title: Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants
Author: Cornelissen, Laura Louise; Kim, Seong-Eun; Purdon, Patrick Lee; Brown, Emery Neal; Berde, Charles Benjamin

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Citation: Cornelissen, Laura, Seong-Eun Kim, Patrick L Purdon, Emery N Brown, and Charles B Berde. 2015. “Age-Dependent Electroencephalogram (EEG) Patterns During Sevoflurane General Anesthesia in Infants.” eLife 4 (June 23). CLOCKSS. doi:10.7554/elife.06513.
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Abstract: Electroencephalogram (EEG) approaches may provide important information about developmental changes in brain-state dynamics during general anesthesia. We used multi-electrode EEG, analyzed with multitaper spectral methods and video recording of body movement to characterize the spatio-temporal dynamics of brain activity in 36 infants 0-6 months old when awake, and during maintenance of and emergence from sevoflurane general anesthesia. During maintenance: (1) slow-delta oscillations were present in all ages; (2) theta and alpha oscillations emerged around 4 months; (3) unlike adults, all infants lacked frontal alpha predominance and coherence. Alpha power was greatest during maintenance, compared to awake and emergence in infants at 4-6 months. During emergence, theta and alpha power decreased with decreasing sevoflurane concentration in infants at 4-6 months. These EEG dynamic differences are likely due to developmental factors including regional differences in synaptogenesis, glucose metabolism, and myelination across the cortex. We demonstrate the need to apply age-adjusted analytic approaches to develop neurophysiologic-based strategies for pediatric anesthetic state monitoring.
Published Version: 10.7554/elife.06513
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32416095
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