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dc.contributor.authorGerweck, Leo Edward
dc.contributor.authorHuang, Peigen
dc.contributor.authorLu, Hsiao-ming
dc.contributor.authorPaganetti, Harald
dc.contributor.authorZhou, Yenong
dc.date.accessioned2017-04-25T20:18:44Z
dc.date.issued2014
dc.identifierQuick submit: 2017-03-22T15:30:32-0400
dc.identifier.citationGerweck, Leo E., Peigen Huang, Hsiao-Ming Lu, Harald Paganetti, and Yenong Zhou. 2014. “Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam–Generated Neutrons.” International Journal of Radiation Oncology*Biology*Physics 89 (1) (May): 161–166. doi:10.1016/j.ijrobp.2014.01.057.en_US
dc.identifier.issn0360-3016en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32435166
dc.description.abstractPurpose To evaluate the lifespan and risk of cancer following whole-body exposure of mice to neutrons generated by a passively scattered clinical SOBP proton beam. Methods and Materials Three hundred young adult female FVB/N mice, 152 test and 148 control, were entered into the experiment. Mice were placed in an annular cassette around a cylindrical phantom, which was positioned lateral to the mid SOBP of a 165 MeV, clinical proton beam. The average distance from the edge of the mid SOBP to the conscious active mice was 21.5 cm. The phantom was irradiated with once daily fractions of 25 Gy, 4 days per week, for 6 weeks. The age at death and cause of death, i.e., cancer and type vs. non-cancer causes, were assessed over the lifespan of the mice. Results Exposure of mice to a dose of 600 Gy of proton beam generated neutrons, reduced the median lifespan of the mice by 4.2% (Kaplan-Meier cumulative survival, P = 0.053). The relative risk of death from cancer in neutron exposed vs. control mice was 1.40 for cancer of all types (P = 0.0006) and 1.22 for solid cancers (P = 0.09). For a typical 60 Gy dose of clinical protons, the observed 22% increased risk of solid cancer would be expected to decrease by a factor of 10. Conclusions Exposure of mice to neutrons generated by a proton dose which exceeds a typical course of radiotherapy by a factor of 10, resulted in a statistically significant increase in the background incidence of leukemia and a marginally significant increase in solid cancer. The results indicate that the risk of out-of-field 2nd solid cancers from SOBP proton generated neutrons and typical treatment schedules, is 6 - 10 times less than is suggested by current neutron risk estimates.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.ijrobp.2014.01.057en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298825/en_US
dash.licenseLAA
dc.titleLifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam–Generated Neutronsen_US
dc.typeJournal Articleen_US
dc.date.updated2017-03-22T19:30:32Z
dc.description.versionAccepted Manuscripten_US
dc.relation.journalInternational Journal of Radiation Oncology*Biology*Physicsen_US
dash.depositing.authorLu, Hsiao-ming
dc.date.available2014
dc.date.available2017-04-25T20:18:44Z
dc.identifier.doi10.1016/j.ijrobp.2014.01.057*
dash.contributor.affiliatedGerweck, Leo
dash.contributor.affiliatedLu, Hsiao-Ming
dash.contributor.affiliatedPaganetti, Harald
dash.contributor.affiliatedHuang, Peigen


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