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dc.contributor.authorMurakami, Yusuke
dc.contributor.authorNotomi, Shoji
dc.contributor.authorHisatomi, Toshio
dc.contributor.authorNakazawa, Toru
dc.contributor.authorIshibashi, Tatsuro
dc.contributor.authorMiller, Joan Whitten
dc.contributor.authorVavvas, Demetrios
dc.date.accessioned2017-04-26T15:32:55Z
dc.date.issued2013
dc.identifierQuick submit: 2013-09-06T02:17:51-04:00
dc.identifier.citationMurakami, Yusuke, Shoji Notomi, Toshio Hisatomi, Toru Nakazawa, Tatsuro Ishibashi, Joan W. Miller, and Demetrios G. Vavvas. “Photoreceptor Cell Death and Rescue in Retinal Detachment and Degenerations.” Progress in Retinal and Eye Research 37 (2013): 114–140.en_US
dc.identifier.issn1350-9462en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32490557
dc.description.abstractPhotoreceptor cell death is the ultimate cause of vision loss in various retinal disorders, including retinal detachment (RD). Photoreceptor cell death has been thought to occur mainly through apoptosis, which is the most characterized form of programmed cell death. The caspase family of cysteine proteases plays a central role for inducing apoptosis, and in experimental models of RD, dying photoreceptor cells exhibit caspase activation; however, there is a paradox that caspase inhibition alone does not provide a sufficient protection against photoreceptor cell loss, suggesting that other mechanisms of cell death are involved. Recent accumulating evidence demonstrates that non-apoptotic forms of cell death, such as autophagy and necrosis, are also regulated by specific molecular machinery, such as those mediated by autophagy-related proteins and receptor-interacting protein kinases, respectively. Here we summarize the current knowledge of cell death signaling and its roles in photoreceptor cell death after RD and other retinal degenerative diseases. A body of studies indicate that not only apoptotic but also autophagic and necrotic signaling are involved in photoreceptor cell death, and that combined targeting of these pathways may be an effective neuroprotective strategy for retinal diseases associated with photoreceptor cell loss.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.preteyeres.2013.08.001en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871865/en_US
dash.licenseLAA
dc.subjectRetina; Macula; Degenerations; Necrosis; Apoptosis; Autophagy; Neuroprotection; Neuroregenerationen_US
dc.titlePhotoreceptor cell death and rescue in retinal detachment and degenerationsen_US
dc.typeJournal Articleen_US
dc.date.updated2013-09-06T06:18:25Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderYusuke Murakami, Shoji Notomi, Toshio Hisatomi, Toru Nakazawa, Tatsuro Ishibashi, Joan W Miller, and Demetrios G Vavvas
dc.relation.journalProgress in Retinal and Eye Researchen_US
dash.depositing.authorVavvas, Demetrios
dc.date.available2017-04-26T15:32:55Z
dc.identifier.doi10.1016/j.preteyeres.2013.08.001*
dash.contributor.affiliatedMiller, Joan
dash.contributor.affiliatedVavvas, Demetrios


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