Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes

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Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes

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Title: Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes
Author: Song, Yong-Ak; Melik, Rohat; Rabie, Amr N.; Ibrahim, Ahmed Mohamed Said; Moses, David; Tan, Ara; Han, Jongyoon; Lin, Samuel J

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Citation: Song, Yong-Ak, Rohat Melik, Amr N. Rabie, Ahmed M. S. Ibrahim, David Moses, Ara Tan, Jongyoon Han, and Samuel J. Lin. 2011. “Electrochemical Activation and Inhibition of Neuromuscular Systems through Modulation of Ion Concentrations with Ion-Selective Membranes.” Nature Materials 10 (12) (October 23): 980–986.
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Abstract: Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations in situ along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes.
Published Version: doi:10.1038/nmat3146
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223285/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32498072
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