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dc.contributor.authorSong, Yong-Ak
dc.contributor.authorMelik, Rohat
dc.contributor.authorRabie, Amr N.
dc.contributor.authorIbrahim, Ahmed Mohamed Said
dc.contributor.authorMoses, David
dc.contributor.authorTan, Ara
dc.contributor.authorHan, Jongyoon
dc.contributor.authorLin, Samuel J
dc.date.accessioned2017-04-26T16:05:22Z
dc.date.issued2011
dc.identifierQuick submit: 2014-03-14T12:14:01-04:00
dc.identifier.citationSong, Yong-Ak, Rohat Melik, Amr N. Rabie, Ahmed M. S. Ibrahim, David Moses, Ara Tan, Jongyoon Han, and Samuel J. Lin. 2011. “Electrochemical Activation and Inhibition of Neuromuscular Systems through Modulation of Ion Concentrations with Ion-Selective Membranes.” Nature Materials 10 (12) (October 23): 980–986.en_US
dc.identifier.issn1476-1122en_US
dc.identifier.issn1476-4660en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32498072
dc.description.abstractConventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations in situ along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes.en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/nmat3146en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223285/en_US
dash.licenseLAA
dc.subjectBiomedical materialsen_US
dc.titleElectrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranesen_US
dc.typeJournal Articleen_US
dc.date.updated2014-03-14T16:15:51Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderSong YA, Melik R, Rabie AN, Ibrahim AM, Moses D, Tan A, Han J, Lin SJ
dc.relation.journalNature Materialsen_US
dash.depositing.authorIbrahim, Ahmed Mohamed Said
dc.date.available2017-04-26T16:05:22Z
dc.identifier.doi10.1038/nmat3146*
dash.contributor.affiliatedIbrahim, Ahmed M. S.
dash.contributor.affiliatedLin, Samuel


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