Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes

DSpace/Manakin Repository

Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes

Show simple item record

dc.contributor.author Song, Yong-Ak
dc.contributor.author Melik, Rohat
dc.contributor.author Rabie, Amr N.
dc.contributor.author Ibrahim, Ahmed Mohamed Said
dc.contributor.author Moses, David
dc.contributor.author Tan, Ara
dc.contributor.author Han, Jongyoon
dc.contributor.author Lin, Samuel J
dc.date.accessioned 2017-04-26T16:05:22Z
dc.date.issued 2011
dc.identifier Quick submit: 2014-03-14T12:14:01-04:00
dc.identifier.citation Song, Yong-Ak, Rohat Melik, Amr N. Rabie, Ahmed M. S. Ibrahim, David Moses, Ara Tan, Jongyoon Han, and Samuel J. Lin. 2011. “Electrochemical Activation and Inhibition of Neuromuscular Systems through Modulation of Ion Concentrations with Ion-Selective Membranes.” Nature Materials 10 (12) (October 23): 980–986. en_US
dc.identifier.issn 1476-1122 en_US
dc.identifier.issn 1476-4660 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:32498072
dc.description.abstract Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations in situ along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes. en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof doi:10.1038/nmat3146 en_US
dc.relation.hasversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223285/ en_US
dash.license LAA
dc.subject Biomedical materials en_US
dc.title Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes en_US
dc.type Journal Article en_US
dc.date.updated 2014-03-14T16:15:51Z
dc.description.version Accepted Manuscript en_US
dc.rights.holder Song YA, Melik R, Rabie AN, Ibrahim AM, Moses D, Tan A, Han J, Lin SJ
dc.relation.journal Nature Materials en_US
dash.depositing.author Ibrahim, Ahmed Mohamed Said
dc.date.available 2017-04-26T16:05:22Z

Files in this item

Files Size Format View
nihms-325595.pdf 852.2Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters