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dc.contributor.authorZhou, Dawang
dc.contributor.authorConrad, Claudius
dc.contributor.authorXia, Fan
dc.contributor.authorPark, Ji-Sun
dc.contributor.authorPayer, Bernhard
dc.contributor.authorYin, Yi
dc.contributor.authorLauwers, Gregory Y.
dc.contributor.authorThasler, Wolfgang
dc.contributor.authorLee, Jeannie T.
dc.contributor.authorAvruch, Joseph
dc.contributor.authorBardeesy, Nabeel
dc.date.accessioned2017-04-26T19:32:38Z
dc.date.issued2009
dc.identifier.citationZhou, Dawang, Claudius Conrad, Fan Xia, Ji-Sun Park, Bernhard Payer, Yi Yin, Gregory Y. Lauwers, et al. 2009. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16(5): 425–438. doi:10.1016/j.ccr.2009.09.026en_US
dc.identifier.issn1535-6108en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32540912
dc.description.abstractHippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila. We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo orthologs, are cleaved and constitutively activated in the mouse liver. Combined Mst1/2 deficiency in the liver results in loss of inhibitory Ser127 phosphorylation of the Yorkie ortholog, Yap1, massive overgrowth, and hepatocellular carcinoma (HCC). Reexpression of Mst1 in HCC-derived cell lines promotes Yap1 Ser127 phosphorylation and inactivation and abrogates their tumorigenicity. Notably, Mst1/2 inactivates Yap1 in liver through an intermediary kinase distinct from Lats1/2. Approximately 30% of human HCCs show low Yap1(Ser127) phosphorylation and a majority exhibit loss of cleaved, activated Mst1. Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.ccr.2009.09.026en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023165/en_US
dash.licenseLAA
dc.subjectcellcycleen_US
dc.titleMst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogeneen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalCancer Cellen_US
dash.depositing.authorLauwers, Gregory Y.
dc.date.available2017-04-26T19:32:38Z
dc.identifier.doi10.1016/j.ccr.2009.09.026*
dash.authorsorderedfalse
dash.contributor.affiliatedPayer, Bernhard
dash.contributor.affiliatedXia, Fan
dash.contributor.affiliatedConrad, Claudius Horst Oskar
dash.contributor.affiliatedAvruch, Joseph
dash.contributor.affiliatedLauwers, Gregory Y.
dash.contributor.affiliatedLee, Jeannie


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