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dc.contributor.authorShiomi, M.
dc.contributor.authorIshida, T.
dc.contributor.authorKobayashi, T.
dc.contributor.authorNitta, N.
dc.contributor.authorSonoda, A.
dc.contributor.authorYamada, S.
dc.contributor.authorKoike, T.
dc.contributor.authorKuniyoshi, N.
dc.contributor.authorMurata, K.
dc.contributor.authorHirata, K.-i.
dc.contributor.authorIto, T.
dc.contributor.authorLibby, Peter
dc.date.accessioned2017-04-27T20:04:13Z
dc.date.issued2013
dc.identifier.citationShiomi, Masashi, Tatsuro Ishida, Tsutomu Kobayashi, Norihisa Nitta, Akinaga Sonoda, Satoshi Yamada, Tomonari Koike, et al. 2013. “Vasospasm of Atherosclerotic Coronary Arteries Precipitates Acute Ischemic Myocardial Damage in Myocardial Infarction–Prone Strain of the Watanabe Heritable Hyperlipidemic RabbitsSignificance.” Arteriosclerosis, Thrombosis, and Vascular Biology 33 (11) (August 29): 2518–2523. doi:10.1161/atvbaha.113.301303.en_US
dc.identifier.issn1079-5642en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32605694
dc.description.abstractObjective—This study tested the hypothesis that vasospasm can trigger coronary plaque injury and acute ischemic myocardial damage. Approach and Results—Myocardial infarction–prone strain of the Watanabe heritable hyperlipidemic rabbits received an intravenous bolus of ergonovine maleate (0.45 µmol/kg) during intravenous infusion of norepinephrine (12 nmol/kg per minute) to provoke coronary spasm in vivo. After this treatment, coronary angiography demonstrated vasospasm, and the ECG showed ischemic abnormalities (ST depression/elevation and T-wave inversion) in 77% of animals (23/30). These changes normalized after nitroglycerin injection. In rabbits that demonstrated these ECG findings for >20 minutes, echocardiograms showed left ventricular wall motion abnormality. Serum levels of heart-type fatty acid–binding protein, cardiac troponin-I, and myoglobin increased markedly 4 hours after spasm provocation. In coronary lesions of myocardial infarction–prone strain of the Watanabe heritable hyperlipidemic rabbits with provoked coronary spasm, we observed intimal injury in 60.9% in the form of endothelial cell protrusions (39.1%), denudation (30.4%), and macrophage extravasation (56.5%). Plaque disruption with luminal thrombus, however, was only seen in 2 of 23 animals (8.7%), and mural microthrombus was rarely observed (4.3%). Conclusions—These observations show that provocation of vasospasm in myocardial infarction–prone strain of the Watanabe heritable hyperlipidemic rabbits associates with subsequent ischemic myocardial damage. Although treatment with spasmogens altered aspects of plaque morphology, for example, endothelial protrusion and macrophage emigration, thrombosis was rare in these animals with chronic atherosclerotic disease.en_US
dc.language.isoen_USen_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.relation.isversionofdoi:10.1161/ATVBAHA.113.301303en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349325/en_US
dash.licenseMETA_ONLY
dc.subjectcardiovascular diseasesen_US
dc.subjectcoronary atherosclerosisen_US
dc.subjectcoronary vasospasmen_US
dc.subjectischemia, myocardiumen_US
dc.subjectmodels, animalen_US
dc.titleVasospasm of Atherosclerotic Coronary Arteries Precipitates Acute Ischemic Myocardial Damage in Myocardial Infarction-Prone Strain of the Watanabe Heritable Hyperlipidemic Rabbitsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalArteriosclerosis, Thrombosis, and Vascular Biologyen_US
dash.depositing.authorLibby, Peter
dash.embargo.until10000-01-01
dc.identifier.doi10.1161/ATVBAHA.113.301303*
dash.authorsorderedfalse
dash.contributor.affiliatedLibby, Peter


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