Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

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Title: Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
Author: Ganna, Andrea; Genovese, Giulio; Howrigan, Daniel P.; Byrnes, Andrea; Kurki, Mitja; Zekavat, Seyedeh M.; Whelan, Christopher W.; Kals, Mart; Nivard, Michel G.; Bloemendal, Alex; Bloom, Jonathan M.; Goldstein, Jacqueline I.; Poterba, Timothy; Seed, Cotton; Handsaker, Robert E.; Natarajan, Pradeep; Mägi, Reedik; Gage, Diane; Robinson, Elise B.; Metspalu, Andres; Salomaa, Veikko; Suvisaari, Jaana; Purcell, Shaun M.; Sklar, Pamela; Kathiresan, Sekar; Daly, Mark J.; McCarroll, Steven A.; Sullivan, Patrick F.; Palotie, Aarno; Esko, Tõnu; Hultman, Christina; Neale, Benjamin M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Ganna, A., G. Genovese, D. P. Howrigan, A. Byrnes, M. Kurki, S. M. Zekavat, C. W. Whelan, et al. 2016. “Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.” Nature neuroscience 19 (12): 1563-1565. doi:10.1038/nn.4404. http://dx.doi.org/10.1038/nn.4404.
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Abstract: Disruptive and damaging ultra-rare variants (URVs) in highly constrained (HC) genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE; −3.1 months; P-value=3.3×10−8). This effect was stronger among high brain-expressed genes and explained more YOE variance than pathogenic copy number variation, but less than common variants. Disruptive and damaging URVs in HC genes influence the determinants of YOE in the general population.
Published Version: doi:10.1038/nn.4404
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127781/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32630722
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