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dc.contributor.authorGanna, Andreaen_US
dc.contributor.authorGenovese, Giulioen_US
dc.contributor.authorHowrigan, Daniel P.en_US
dc.contributor.authorByrnes, Andreaen_US
dc.contributor.authorKurki, Mitjaen_US
dc.contributor.authorZekavat, Seyedeh M.en_US
dc.contributor.authorWhelan, Christopher W.en_US
dc.contributor.authorKals, Marten_US
dc.contributor.authorNivard, Michel G.en_US
dc.contributor.authorBloemendal, Alexen_US
dc.contributor.authorBloom, Jonathan M.en_US
dc.contributor.authorGoldstein, Jacqueline I.en_US
dc.contributor.authorPoterba, Timothyen_US
dc.contributor.authorSeed, Cottonen_US
dc.contributor.authorHandsaker, Robert E.en_US
dc.contributor.authorNatarajan, Pradeepen_US
dc.contributor.authorMägi, Reediken_US
dc.contributor.authorGage, Dianeen_US
dc.contributor.authorRobinson, Elise B.en_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorSalomaa, Veikkoen_US
dc.contributor.authorSuvisaari, Jaanaen_US
dc.contributor.authorPurcell, Shaun M.en_US
dc.contributor.authorSklar, Pamelaen_US
dc.contributor.authorKathiresan, Sekaren_US
dc.contributor.authorDaly, Mark J.en_US
dc.contributor.authorMcCarroll, Steven A.en_US
dc.contributor.authorSullivan, Patrick F.en_US
dc.contributor.authorPalotie, Aarnoen_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorHultman, Christinaen_US
dc.contributor.authorNeale, Benjamin M.en_US
dc.date.accessioned2017-05-01T19:28:50Z
dc.date.issued2016en_US
dc.identifier.citationGanna, A., G. Genovese, D. P. Howrigan, A. Byrnes, M. Kurki, S. M. Zekavat, C. W. Whelan, et al. 2016. “Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.” Nature neuroscience 19 (12): 1563-1565. doi:10.1038/nn.4404. http://dx.doi.org/10.1038/nn.4404.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32630722
dc.description.abstractDisruptive and damaging ultra-rare variants (URVs) in highly constrained (HC) genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE; −3.1 months; P-value=3.3×10−8). This effect was stronger among high brain-expressed genes and explained more YOE variance than pathogenic copy number variation, but less than common variants. Disruptive and damaging URVs in HC genes influence the determinants of YOE in the general population.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nn.4404en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127781/pdf/en
dash.licenseLAAen_US
dc.titleUltra-rare disruptive and damaging mutations influence educational attainment in the general populationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature neuroscienceen
dash.depositing.authorGanna, Andreaen_US
dc.date.available2017-05-01T19:28:50Z
dc.identifier.doi10.1038/nn.4404*
dash.authorsorderedfalse
dash.contributor.affiliatedHandsaker, Robert
dash.contributor.affiliatedByrnes, Andrea
dash.contributor.affiliatedWhelan, Christopher W.
dash.contributor.affiliatedRobinson, Elise
dash.contributor.affiliatedHowrigan, Daniel
dash.contributor.affiliatedGanna, Andrea
dash.contributor.affiliatedNeale, Benjamin
dash.contributor.affiliatedNatarajan, Pradeep
dash.contributor.affiliatedMcCarroll, Steven
dash.contributor.affiliatedGenovese, Giulio
dash.contributor.affiliatedKurki, Mitja
dash.contributor.affiliatedDaly, Mark
dash.contributor.affiliatedPalotie, Aarno


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