Replication of a genetic variant for prostate cancer-specific mortality

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Replication of a genetic variant for prostate cancer-specific mortality

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Title: Replication of a genetic variant for prostate cancer-specific mortality
Author: Penney, Kathryn Lee; Shul, Irene; Feng, Ziding; Sesso, Howard David; Stampfer, Meir Jonathan; Stanford, Janet

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Citation: Penney, K L, I M Shui, Z Feng, H D Sesso, M J Stampfer, and J L Stanford. 2015. “Replication of a Genetic Variant for Prostate Cancer-Specific Mortality.” Prostate Cancer Prostatic Dis 18 (3) (May 5): 260–263. doi:10.1038/pcan.2015.18.
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Abstract: Results: One SNP, rs5993891 in the ARVCF gene on chromosome 22q11, which had also replicated in the Swedish cohort, was also significantly associated with PCSM in the PHS cohort (hazard ratio (HR)=0.32; P=0.01). When we tested this SNP in an additional cohort (Health Professionals Follow-up Study, HPFS), the association was null (HR=0.95, P=0.90); however, a meta-analysis across all studies showed a statistically significant association with a HR of 0.52 (0.29-0.93, P=0.03).
Conclusions: The association of rs5993891 with PCSM was further replicated in PHS and remains significant in a meta-analysis, though there was no association in HPFS. This SNP may contribute to a genetic panel of SNPs to determine at diagnosis whether a patient is more likely to exhibit an indolent or aggressive form of PCa. This study also emphasizes the importance of multiple rounds of replication.
Published Version: 10.1038/pcan.2015.18
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32663226
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