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dc.contributor.authorNishino, Mizuki
dc.contributor.authorSholl, Lynette Marie
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorRamaiya, Nikhil
dc.contributor.authorHodi, Frank Stephen
dc.date.accessioned2017-05-18T15:38:03Z
dc.date.issued2015
dc.identifier.citationNishino, Mizuki, Lynette M. Sholl, Hiroto Hatabu, Nikhil H. Ramaiya, and F. Stephen Hodi. 2015. “Anti–PD-1–Related Pneumonitis During Cancer Immunotherapy.” New England Journal of Medicine 373 (3) (July 16): 288–290. doi:10.1056/nejmc1505197.en_US
dc.identifier.issn0028-4793en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32705581
dc.description.abstractThe use of antibodies against programmed cell death 1 (PD-1), which block inhibitory T-cell checkpoints, is a promising new therapy for advanced cancers.1 Recent trials have shown substantial clinical activity of anti–PD-1 antibodies in advanced cancers and led to the approvals of these agents, including pembrolizumab for melanoma and nivolumab for melanoma and squamous-cell lung cancer.2-4 Pneumonitis related to the use of antibodies against PD-1 is an immune-mediated toxic effect that resulted in three drug-related deaths in a phase 1 trial.1 Clinical identification and management of pneumonitis are contingent on radiographic assessment. We report three cases of pneumonitis associated with the use of anti–PD-1 antibodies in patients with melanoma.en_US
dc.language.isoen_USen_US
dc.publisherNew England Journal of Medicine (NEJM/MMS)en_US
dc.relation.isversionofdoi:10.1056/NEJMc1505197en_US
dash.licenseLAA
dc.titleAnti–PD-1–Related Pneumonitis during Cancer Immunotherapyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNew England Journal of Medicineen_US
dash.depositing.authorSholl, Lynette Marie
dc.date.available2017-05-18T15:38:03Z
dc.identifier.doi10.1056/NEJMc1505197*
dash.contributor.affiliatedHatabu, Hiroto
dash.contributor.affiliatedHodi, Frank
dash.contributor.affiliatedRamaiya, Nikhil H.
dash.contributor.affiliatedSholl, Lynette


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