Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination

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Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination

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Title: Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination
Author: Hennessy, Elisabeth Therese; Betley, Theodore A

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Citation: Hennessy, E. T., and T. A. Betley. 2013. “Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination.” Science 340 (6132) (May 3): 591–595.
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Abstract: The manipulation of traditionally unreactive functional groups is of paramount importance in modern chemical synthesis. We have developed an iron-dipyrrinato catalyst that leverages the reactivity of iron-borne metal-ligand multiple bonds to promote the direct amination of aliphatic C–H bonds. Exposure of organic azides to the iron dipyrrinato catalyst furnishes saturated, cyclic amine products (N-heterocycles) bearing complex core-substitution patterns. This study highlights the development of C–H bond functionalization chemistry for the formation of saturated, cyclic amine products and should find broad application in the context of both pharmaceuticals and natural product synthesis.
Published Version: doi:10.1126/science.1233701
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32969807
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