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dc.contributor.authorHennessy, Elisabeth Therese
dc.contributor.authorBetley, Theodore A
dc.date.accessioned2017-06-09T15:17:47Z
dc.date.issued2013
dc.identifier.citationHennessy, E. T., and T. A. Betley. 2013. “Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination.” Science 340 (6132) (May 3): 591–595.en_US
dc.identifier.issn0036-8075en_US
dc.identifier.issn1095-9203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32969807
dc.description.abstractThe manipulation of traditionally unreactive functional groups is of paramount importance in modern chemical synthesis. We have developed an iron-dipyrrinato catalyst that leverages the reactivity of iron-borne metal-ligand multiple bonds to promote the direct amination of aliphatic C–H bonds. Exposure of organic azides to the iron dipyrrinato catalyst furnishes saturated, cyclic amine products (N-heterocycles) bearing complex core-substitution patterns. This study highlights the development of C–H bond functionalization chemistry for the formation of saturated, cyclic amine products and should find broad application in the context of both pharmaceuticals and natural product synthesis.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofdoi:10.1126/science.1233701en_US
dash.licenseMETA_ONLY
dc.titleComplex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Aminationen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalScienceen_US
dash.depositing.authorBetley, Theodore A
dash.embargo.until10000-01-01
dc.identifier.doi10.1126/science.1233701*
dash.contributor.affiliatedHennessy, Elisabeth
dash.contributor.affiliatedBetley, Theodore


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