Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

DSpace/Manakin Repository

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

Citable link to this page

 

 
Title: Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
Author: Blum, Barak; Hrvatin, Sini[sbreve]?a; Schuetz, Christian; Bonal, Claire; Rezania, Alireza; Melton, Douglas A.

Note: Order does not necessarily reflect citation order of authors.

Citation: Blum, Barak, Sinisa Hrvatin, Christian Schuetz, Claire Bonal, Alireza Rezania, and Douglas A Melton. 2012. “Functional Beta-Cell Maturation Is Marked by an Increased Glucose Threshold and by Expression of Urocortin 3.” Nature Biotechnology 30 (3) (February 26): 261–264.
Access Status: Full text of the requested work is not available in DASH at this time (“dark deposit”). For more information on dark deposits, see our FAQ.
Full Text & Related Files:
Abstract: Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
Published Version: doi:10.1038/nbt.2141
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32969828
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters