Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
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Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Author
Bonal, Claire
Rezania, Alireza
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https://doi.org/10.1038/nbt.2141Metadata
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Blum, Barak, Sinisa Hrvatin, Christian Schuetz, Claire Bonal, Alireza Rezania, and Douglas A Melton. 2012. “Functional Beta-Cell Maturation Is Marked by an Increased Glucose Threshold and by Expression of Urocortin 3.” Nature Biotechnology 30 (3) (February 26): 261–264.Abstract
Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:32969828
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