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dc.contributor.authorYi, Peng
dc.contributor.authorPark, Ji Sun
dc.contributor.authorMelton, Douglas A.
dc.date.accessioned2017-06-09T15:44:05Z
dc.date.issued2013
dc.identifierQuick submit: 2014-02-07T09:54:31-05:00
dc.identifier.citationYi, Peng, Ji-Sun Park, and Douglas A. Melton. 2013. “Betatrophin: A Hormone That Controls Pancreatic β Cell Proliferation.” Cell 153 (4) (May): 747–758. doi:10.1016/j.cell.2013.04.008. http://dx.doi.org/10.1016/j.cell.2013.04.008.en_US
dc.identifier.issn0092-8674en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:32969830
dc.description.abstractReplenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver and fat. Expression of betatrophin correlates with β cell proliferation in other mouse models of insulin resistance and during gestation. Transient expression of betatrophin in mouse liver significantly and specifically promotes pancreatic β cell proliferation, expands β cell mass, and improves glucose tolerance. Thus, betatrophin treatment could augment or replace insulin injections by increasing the number of endogenous insulin-producing cells in diabetics.en_US
dc.description.sponsorshipStem Cell and Regenerative Biologyen_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.cell.2013.04.008en_US
dc.relation.isversionofdoi:10.1016/j.cell.2013.04.008en_US
dash.licenseMETA_ONLY
dc.titleBetatrophin: A Hormone that Controls Pancreatic β Cell Proliferationen_US
dc.typeJournal Articleen_US
dc.date.updated2014-02-07T14:56:04Z
dc.description.versionVersion of Recorden_US
dc.rights.holderYi P, Park JS, Melton, DA
dc.relation.journalCellen_US
dash.depositing.authorMelton, Douglas A.
dash.embargo.until10000-01-01
dc.identifier.doi10.1016/j.cell.2013.04.008*
dash.contributor.affiliatedPark, Ji Sun
dash.contributor.affiliatedMelton, Douglas
dash.contributor.affiliatedYi, Peng


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