dc.contributor.author | Yi, Peng | |
dc.contributor.author | Park, Ji Sun | |
dc.contributor.author | Melton, Douglas A. | |
dc.date.accessioned | 2017-06-09T15:44:05Z | |
dc.date.issued | 2013 | |
dc.identifier | Quick submit: 2014-02-07T09:54:31-05:00 | |
dc.identifier.citation | Yi, Peng, Ji-Sun Park, and Douglas A. Melton. 2013. “Betatrophin: A Hormone That Controls Pancreatic β Cell Proliferation.” Cell 153 (4) (May): 747–758. doi:10.1016/j.cell.2013.04.008. http://dx.doi.org/10.1016/j.cell.2013.04.008. | en_US |
dc.identifier.issn | 0092-8674 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:32969830 | |
dc.description.abstract | Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver and fat. Expression of betatrophin correlates with β cell proliferation in other mouse models of insulin resistance and during gestation. Transient expression of betatrophin in mouse liver significantly and specifically promotes pancreatic β cell proliferation, expands β cell mass, and improves glucose tolerance. Thus, betatrophin treatment could augment or replace insulin injections by increasing the number of endogenous insulin-producing cells in diabetics. | en_US |
dc.description.sponsorship | Stem Cell and Regenerative Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier BV | en_US |
dc.relation.isversionof | 10.1016/j.cell.2013.04.008 | en_US |
dc.relation.isversionof | doi:10.1016/j.cell.2013.04.008 | en_US |
dash.license | META_ONLY | |
dc.title | Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation | en_US |
dc.type | Journal Article | en_US |
dc.date.updated | 2014-02-07T14:56:04Z | |
dc.description.version | Version of Record | en_US |
dc.rights.holder | Yi P, Park JS, Melton, DA | |
dc.relation.journal | Cell | en_US |
dash.depositing.author | Melton, Douglas A. | |
dash.embargo.until | 10000-01-01 | |
dc.identifier.doi | 10.1016/j.cell.2013.04.008 | * |
dash.contributor.affiliated | Park, Ji Sun | |
dash.contributor.affiliated | Melton, Douglas | |
dash.contributor.affiliated | Yi, Peng | |