A simple tool to improve pluripotent stem cell differentiation

DSpace/Manakin Repository

A simple tool to improve pluripotent stem cell differentiation

Citable link to this page

 

 
Title: A simple tool to improve pluripotent stem cell differentiation
Author: Chetty, Sundari; Pagliuca, Felicia Jane; Honore, Christian; Kweudjeu, Anastasie; Rezania, Alireza; Melton, Douglas A.

Note: Order does not necessarily reflect citation order of authors.

Citation: Chetty, Sundari, Felicia Walton Pagliuca, Christian Honore, Anastasie Kweudjeu, Alireza Rezania, and Douglas A Melton. 2013. “A Simple Tool to Improve Pluripotent Stem Cell Differentiation.” Nature Methods 10 (6) (April 14): 553–556. doi:10.1038/nmeth.2442. http://dx.doi.org/10.1038/nmeth.2442.
Access Status: Full text of the requested work is not available in DASH at this time (“dark deposit”). For more information on dark deposits, see our FAQ.
Full Text & Related Files:
Abstract: We describe a method to help overcome restrictions on the differentiation propensities of human pluripotent stem cells. Culturing pluripotent stem cells in dimethylsulfoxide (DMSO) activates the retinoblastoma protein, increases the proportion of cells in the early G1 phase of the cell cycle and, in more than 25 embryonic and induced pluripotent stem cell lines, improves directed differentiation into multiple lineages. DMSO treatment also improves differentiation into terminal cell types in several cell lines.
Published Version: 10.1038/nmeth.2442
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:32969831
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters