Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
View/ Open
66383864.pdf (3.433Mb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Published Version
https://doi.org/10.1016/j.neuron.2012.03.017Metadata
Show full item recordCitation
Watabe-Uchida, Mitsuko, Lisa Zhu, Sachie K. Ogawa, Archana Vamanrao, and Naoshige Uchida. 2012. Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons. Neuron 74, no. 5: 858–873.Abstract
Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inputs from a more diverse collection of areas than previously thought, including autonomic, motor, and somatosensory areas. SNc and VTA dopamine neurons receive contrasting excitatory inputs: the former from the somatosensory/motor cortex and subthalamic nucleus, which may explain their short-latency responses to salient events; and the latter from the lateral hypothalamus, which may explain their involvement in value coding. We demonstrate that neurons in the striatum that project directly to dopamine neurons form patches in both the dorsal and ventral striatum, whereas those projecting to GABAergic neurons are distributed in the matrix compartment. Neuron-type-specific connectivity lays a foundation for studying how dopamine neurons compute outputs.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:32969844
Collections
- FAS Scholarly Articles [17813]
Contact administrator regarding this item (to report mistakes or request changes)
Comments made during the workflow steps
FAR 2013 Uchida emailed 2016-04-20 MM Uchida emailed 2017-02-18 MM meta.dark