Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

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Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

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Title: Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Author: Nishita, Michiru; Park, Seung-Yeol; Nishio, Tadashi; Kamizaki, Koki; Wang, ZhiChao; Tamada, Kota; Takumi, Toru; Hashimoto, Ryuju; Otani, Hiroki; Pazour, Gregory J.; Hsu, Victor W.; Minami, Yasuhiro

Note: Order does not necessarily reflect citation order of authors.

Citation: Nishita, M., S. Park, T. Nishio, K. Kamizaki, Z. Wang, K. Tamada, T. Takumi, et al. 2017. “Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.” Scientific Reports 7 (1): 1. doi:10.1038/s41598-016-0028-x. http://dx.doi.org/10.1038/s41598-016-0028-x.
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Abstract: Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.
Published Version: doi:10.1038/s41598-016-0028-x
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428335/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33029701
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