A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells

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A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells

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Title: A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells
Author: Ersing, Ina; Nobre, Luis; Wang, Liang Wei; Soday, Lior; Ma, Yijie; Paulo, Joao A.; Narita, Yohei; Ashbaugh, Camille W.; Jiang, Chang; Grayson, Nicholas E.; Kieff, Elliott; Gygi, Steven P.; Weekes, Michael P.; Gewurz, Benjamin E.

Note: Order does not necessarily reflect citation order of authors.

Citation: Ersing, I., L. Nobre, L. W. Wang, L. Soday, Y. Ma, J. A. Paulo, Y. Narita, et al. 2017. “A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells.” Cell Reports 19 (7): 1479-1493. doi:10.1016/j.celrep.2017.04.062. http://dx.doi.org/10.1016/j.celrep.2017.04.062.
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Abstract: Summary Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication to gain insights into virus-host interactions, using conditional Burkitt lymphoma models of type I and II EBV infection. We quantified profiles of >8,000 cellular and 69 EBV proteins, including >500 plasma membrane proteins, providing temporal views of the lytic B cell proteome and EBV virome. Our approach revealed EBV-induced remodeling of cell cycle, innate and adaptive immune pathways, including upregulation of the complement cascade and proteasomal degradation of the B cell receptor complex, conserved between EBV types I and II. Cross-comparison with proteomic analyses of human cytomegalovirus infection and of a Kaposi-sarcoma-associated herpesvirus immunoevasin identified host factors targeted by multiple herpesviruses. Our results provide an important resource for studies of EBV replication.
Published Version: doi:10.1016/j.celrep.2017.04.062
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446956/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33029761
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