Using Procalcitonin to Guide Antibiotic Therapy

DSpace/Manakin Repository

Using Procalcitonin to Guide Antibiotic Therapy

Citable link to this page

 

 
Title: Using Procalcitonin to Guide Antibiotic Therapy
Author: Rhee, Chanu
Citation: Rhee, Chanu. 2016. “Using Procalcitonin to Guide Antibiotic Therapy.” Open Forum Infectious Diseases 4 (1): ofw249. doi:10.1093/ofid/ofw249. http://dx.doi.org/10.1093/ofid/ofw249.
Full Text & Related Files:
Abstract: Abstract Procalcitonin levels rise in response to systemic inflammation, especially of bacterial origin. Multiple randomized controlled trials have demonstrated that procalcitonin-based algorithms can safely reduce antibiotic use in 2 clinical scenarios. First, in stable, low-risk patients with respiratory infections, procalcitonin levels of <0.25 µg/L can guide the decision to withhold antibiotics or stop therapy early. Second, in critically ill patients with suspected sepsis, clinicians should not initially withhold antibiotics, but procalcitonin levels of <0.5 µg/L or levels that decrease by ≥80% from peak can guide discontinuation once patients stabilize. The recent stop antibiotics on procalcitonin guidance study (SAPS), the largest procalcitonin trial to date, demonstrated reduction in both antibiotic exposure and mortality in critically ill patients. Although procalcitonin is ready for routine use, future research should examine optimal strategies for implementation in hospitals, its real-world impact on clinical outcomes and costs, its applicability to immunocompromised patients, and the generalizability of trials to the US population.
Published Version: doi:10.1093/ofid/ofw249
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414114/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33029781
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters