Targeted Delivery of Immunomodulators to Lymph Nodes
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Author
Yin, Qian
Ohori, Shunsuke
Tang, Li
Cai, Kaimin
Maarouf, Omar
Kefaloyianni, Eirini
Loughhead, Scott
Petr, Jarolim
Sun, Qidi
Kwon, Mincheol
Cheng, Jianjun
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1016/j.celrep.2016.04.007Metadata
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Azzi, J., Q. Yin, M. Uehara, S. Ohori, L. Tang, K. Cai, T. Ichimura, et al. 2016. “Targeted Delivery of Immunomodulators to Lymph Nodes.” Cell reports 15 (6): 1202-1213. doi:10.1016/j.celrep.2016.04.007. http://dx.doi.org/10.1016/j.celrep.2016.04.007.Abstract
SUMMARY Active-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node address in molecules expressed by high endothelial venules of lymph nodes. By mimicking lymphocyte trafficking to the lymph nodes, we have engineered MECA79-coated microparticles containing an immunosuppressive medication, tacrolimus. Following intravenous administration, MECA79-bearing particles showed marked accumulation in the draining lymph nodes of transplanted animals. Using an allograft heart transplant model, we show that targeted lymph node delivery of microparticles containing tacrolimus can prolong heart allograft survival with negligible changes in tacrolimus serum level. Using MECA79 conjugation, we have demonstrated targeted delivery of tacrolimus to the lymph nodes following systemic administration, with the capacity for immune modulation in vivo.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973867/pdf/Terms of Use
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