A rapidly-acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

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A rapidly-acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

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Title: A rapidly-acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH
Author: Fenselau, Henning; Campbell, John N.; Verstegen, Anne M.J.; Madara, Joseph C.; Xu, Jie; Shah, Bhavik P.; Resch, Jon M.; Yang, Zongfang; Mandelblat-Cerf, Yael; Livneh, Yoav; Lowell, Bradford B.

Note: Order does not necessarily reflect citation order of authors.

Citation: Fenselau, H., J. N. Campbell, A. M. Verstegen, J. C. Madara, J. Xu, B. P. Shah, J. M. Resch, et al. 2016. “A rapidly-acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH.” Nature neuroscience 20 (1): 42-51. doi:10.1038/nn.4442. http://dx.doi.org/10.1038/nn.4442.
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Abstract: Arcuate nucleus (ARC) neurons sense the fed/fasted state and regulate hunger. Agouti-related protein (ARCAgRP) neurons are stimulated by fasting, and once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP neurons. They are regulated in an opposite fashion and decrease hunger. However, unlike ARCAgRP neurons, ARCPOMC neurons are extremely slow in affecting hunger (many hours). Thus, a temporally analogous, rapid ARC satiety pathway does not exist or is presently unidentified. Here, we show that glutamate-releasing ARC neurons expressing oxytocin receptor, unlike ARCPOMC neurons, rapidly cause satiety when chemo- or optogenetically manipulated. These glutamatergic ARC projections synaptically converge with GABAergic ARCAgRP projections on melanocortin-4 receptor (MC4R)-expressing satiety neurons in the paraventricular hypothalamus (PVHMC4R neurons). Importantly, transmission across the ARCGlutamatergic→PVHMC4R synapse is potentiated by the ARCPOMC neuron-derived MC4R agonist, α-MSH. This excitatory ARC→PVH satiety circuit, and its modulation by α-MSH, provides new insight into regulation of hunger/satiety.
Published Version: doi:10.1038/nn.4442
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191921/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33029878
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