Show simple item record

dc.contributor.authorJustice, Anne E.en_US
dc.contributor.authorWinkler, Thomas W.en_US
dc.contributor.authorFeitosa, Mary F.en_US
dc.contributor.authorGraff, Misaen_US
dc.contributor.authorFisher, Virginia A.en_US
dc.contributor.authorYoung, Kristinen_US
dc.contributor.authorBarata, Llildaen_US
dc.contributor.authorDeng, Xuanen_US
dc.contributor.authorCzajkowski, Jaceken_US
dc.contributor.authorHadley, Daviden_US
dc.contributor.authorNgwa, Julius S.en_US
dc.contributor.authorAhluwalia, Tarunveer S.en_US
dc.contributor.authorChu, Audrey Y.en_US
dc.contributor.authorHeard-Costa, Nancy L.en_US
dc.contributor.authorLim, Eliseen_US
dc.contributor.authorPerez, Jeremiahen_US
dc.contributor.authorEicher, John D.en_US
dc.contributor.authorKutalik, Zoltánen_US
dc.contributor.authorXue, Lutingen_US
dc.contributor.authorMahajan, Anubhaen_US
dc.contributor.authorRenström, Fridaen_US
dc.contributor.authorWu, Josephen_US
dc.contributor.authorQi, Qibinen_US
dc.contributor.authorAhmad, Shafqaten_US
dc.contributor.authorAlfred, Tamunoen_US
dc.contributor.authorAmin, Najafen_US
dc.contributor.authorBielak, Lawrence F.en_US
dc.contributor.authorBonnefond, Amelieen_US
dc.contributor.authorBragg, Jenniferen_US
dc.contributor.authorCadby, Gemmaen_US
dc.contributor.authorChittani, Martinaen_US
dc.contributor.authorCoggeshall, Scotten_US
dc.contributor.authorCorre, Tanguyen_US
dc.contributor.authorDirek, Neseen_US
dc.contributor.authorEriksson, Joelen_US
dc.contributor.authorFischer, Kristaen_US
dc.contributor.authorGorski, Mathiasen_US
dc.contributor.authorNeergaard Harder, Marieen_US
dc.contributor.authorHorikoshi, Momokoen_US
dc.contributor.authorHuang, Taoen_US
dc.contributor.authorHuffman, Jennifer E.en_US
dc.contributor.authorJackson, Anne U.en_US
dc.contributor.authorJustesen, Johanne Marieen_US
dc.contributor.authorKanoni, Stavroulaen_US
dc.contributor.authorKinnunen, Leenaen_US
dc.contributor.authorKleber, Marcus E.en_US
dc.contributor.authorKomulainen, Pirjoen_US
dc.contributor.authorKumari, Meenaen_US
dc.contributor.authorLim, Unheeen_US
dc.contributor.authorLuan, Jian'anen_US
dc.contributor.authorLyytikäinen, Leo-Pekkaen_US
dc.contributor.authorMangino, Massimoen_US
dc.contributor.authorManichaikul, Anien_US
dc.contributor.authorMarten, Jonathanen_US
dc.contributor.authorMiddelberg, Rita P. S.en_US
dc.contributor.authorMüller-Nurasyid, Martinaen_US
dc.contributor.authorNavarro, Pauen_US
dc.contributor.authorPérusse, Louisen_US
dc.contributor.authorPervjakova, Nataliaen_US
dc.contributor.authorSarti, Cinziaen_US
dc.contributor.authorSmith, Albert Vernonen_US
dc.contributor.authorSmith, Jennifer A.en_US
dc.contributor.authorStančáková, Alenaen_US
dc.contributor.authorStrawbridge, Rona J.en_US
dc.contributor.authorStringham, Heather M.en_US
dc.contributor.authorSung, Yun Juen_US
dc.contributor.authorTanaka, Toshikoen_US
dc.contributor.authorTeumer, Alexanderen_US
dc.contributor.authorTrompet, Stellaen_US
dc.contributor.authorvan der Laan, Sander W.en_US
dc.contributor.authorvan der Most, Peter J.en_US
dc.contributor.authorVan Vliet-Ostaptchouk, Jana V.en_US
dc.contributor.authorVedantam, Sailaja L.en_US
dc.contributor.authorVerweij, Nieken_US
dc.contributor.authorVink, Jacqueline M.en_US
dc.contributor.authorVitart, Veroniqueen_US
dc.contributor.authorWu, Yingen_US
dc.contributor.authorYengo, Loicen_US
dc.contributor.authorZhang, Weihuaen_US
dc.contributor.authorHua Zhao, Jingen_US
dc.contributor.authorZimmermann, Martina E.en_US
dc.contributor.authorZubair, Nihaen_US
dc.contributor.authorAbecasis, Gonçalo R.en_US
dc.contributor.authorAdair, Linda S.en_US
dc.contributor.authorAfaq, Saimaen_US
dc.contributor.authorAfzal, Uzmaen_US
dc.contributor.authorBakker, Stephan J. L.en_US
dc.contributor.authorBartz, Traci M.en_US
dc.contributor.authorBeilby, Johnen_US
dc.contributor.authorBergman, Richard N.en_US
dc.contributor.authorBergmann, Svenen_US
dc.contributor.authorBiffar, Reineren_US
dc.contributor.authorBlangero, Johnen_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorBonnycastle, Lori L.en_US
dc.contributor.authorBottinger, Erwinen_US
dc.contributor.authorBraga, Danieleen_US
dc.contributor.authorBuckley, Brendan M.en_US
dc.contributor.authorBuyske, Steveen_US
dc.contributor.authorCampbell, Harryen_US
dc.contributor.authorChambers, John C.en_US
dc.contributor.authorCollins, Francis S.en_US
dc.contributor.authorCurran, Joanne E.en_US
dc.contributor.authorde Borst, Gert J.en_US
dc.contributor.authorde Craen, Anton J. M.en_US
dc.contributor.authorde Geus, Eco J. C.en_US
dc.contributor.authorDedoussis, Georgeen_US
dc.contributor.authorDelgado, Graciela E.en_US
dc.contributor.authorden Ruijter, Hester M.en_US
dc.contributor.authorEiriksdottir, Gudnyen_US
dc.contributor.authorEriksson, Anna L.en_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorFaul, Jessica D.en_US
dc.contributor.authorFord, Ianen_US
dc.contributor.authorForrester, Terrenceen_US
dc.contributor.authorGertow, Karlen_US
dc.contributor.authorGigante, Brunaen_US
dc.contributor.authorGlorioso, Nicolaen_US
dc.contributor.authorGong, Jianen_US
dc.contributor.authorGrallert, Haralden_US
dc.contributor.authorGrammer, Tanja B.en_US
dc.contributor.authorGrarup, Nielsen_US
dc.contributor.authorHaitjema, Saskiaen_US
dc.contributor.authorHallmans, Göranen_US
dc.contributor.authorHamsten, Andersen_US
dc.contributor.authorHansen, Torbenen_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorHartman, Catharina A.en_US
dc.contributor.authorHassinen, Maijaen_US
dc.contributor.authorHastie, Nicholas D.en_US
dc.contributor.authorHeath, Andrew C.en_US
dc.contributor.authorHernandez, Denaen_US
dc.contributor.authorHindorff, Luciaen_US
dc.contributor.authorHocking, Lynne J.en_US
dc.contributor.authorHollensted, Metteen_US
dc.contributor.authorHolmen, Oddgeir L.en_US
dc.contributor.authorHomuth, Georgen_US
dc.contributor.authorJan Hottenga, Joukeen_US
dc.contributor.authorHuang, Jieen_US
dc.contributor.authorHung, Josephen_US
dc.contributor.authorHutri-Kähönen, Ninaen_US
dc.contributor.authorIngelsson, Eriken_US
dc.contributor.authorJames, Alan L.en_US
dc.contributor.authorJansson, John-Oloven_US
dc.contributor.authorJarvelin, Marjo-Riittaen_US
dc.contributor.authorJhun, Min A.en_US
dc.contributor.authorJørgensen, Marit E.en_US
dc.contributor.authorJuonala, Markusen_US
dc.contributor.authorKähönen, Mikaen_US
dc.contributor.authorKarlsson, Magnusen_US
dc.contributor.authorKoistinen, Heikki A.en_US
dc.contributor.authorKolcic, Ivanaen_US
dc.contributor.authorKolovou, Genovefaen_US
dc.contributor.authorKooperberg, Charlesen_US
dc.contributor.authorKrämer, Bernhard K.en_US
dc.contributor.authorKuusisto, Johannaen_US
dc.contributor.authorKvaløy, Kirstien_US
dc.contributor.authorLakka, Timo A.en_US
dc.contributor.authorLangenberg, Claudiaen_US
dc.contributor.authorLauner, Lenore J.en_US
dc.contributor.authorLeander, Karinen_US
dc.contributor.authorLee, Nanette R.en_US
dc.contributor.authorLind, Larsen_US
dc.contributor.authorLindgren, Cecilia M.en_US
dc.contributor.authorLinneberg, Allanen_US
dc.contributor.authorLobbens, Stephaneen_US
dc.contributor.authorLoh, Marieen_US
dc.contributor.authorLorentzon, Mattiasen_US
dc.contributor.authorLuben, Roberten_US
dc.contributor.authorLubke, Gittaen_US
dc.contributor.authorLudolph-Donislawski, Anjaen_US
dc.contributor.authorLupoli, Saraen_US
dc.contributor.authorMadden, Pamela A. F.en_US
dc.contributor.authorMännikkö, Reijaen_US
dc.contributor.authorMarques-Vidal, Pedroen_US
dc.contributor.authorMartin, Nicholas G.en_US
dc.contributor.authorMcKenzie, Colin A.en_US
dc.contributor.authorMcKnight, Barbaraen_US
dc.contributor.authorMellström, Danen_US
dc.contributor.authorMenni, Cristinaen_US
dc.contributor.authorMontgomery, Grant W.en_US
dc.contributor.authorMusk, AW (Bill)en_US
dc.contributor.authorNarisu, Narisuen_US
dc.contributor.authorNauck, Matthiasen_US
dc.contributor.authorNolte, Ilja M.en_US
dc.contributor.authorOldehinkel, Albertine J.en_US
dc.contributor.authorOlden, Matthiasen_US
dc.contributor.authorOng, Ken K.en_US
dc.contributor.authorPadmanabhan, Sandoshen_US
dc.contributor.authorPeyser, Patricia A.en_US
dc.contributor.authorPisinger, Charlottaen_US
dc.contributor.authorPorteous, David J.en_US
dc.contributor.authorRaitakari, Olli T.en_US
dc.contributor.authorRankinen, Tuomoen_US
dc.contributor.authorRao, D. C.en_US
dc.contributor.authorRasmussen-Torvik, Laura J.en_US
dc.contributor.authorRawal, Rajeshen_US
dc.contributor.authorRice, Trevaen_US
dc.contributor.authorRidker, Paul M.en_US
dc.contributor.authorRose, Lynda M.en_US
dc.contributor.authorBien, Stephanie A.en_US
dc.contributor.authorRudan, Igoren_US
dc.contributor.authorSanna, Serenaen_US
dc.contributor.authorSarzynski, Mark A.en_US
dc.contributor.authorSattar, Naveeden_US
dc.contributor.authorSavonen, Kaien_US
dc.contributor.authorSchlessinger, Daviden_US
dc.contributor.authorScholtens, Salomeen_US
dc.contributor.authorSchurmann, Claudiaen_US
dc.contributor.authorScott, Robert A.en_US
dc.contributor.authorSennblad, Bengten_US
dc.contributor.authorSiemelink, Marten A.en_US
dc.contributor.authorSilbernagel, Güntheren_US
dc.contributor.authorSlagboom, P Elineen_US
dc.contributor.authorSnieder, Harolden_US
dc.contributor.authorStaessen, Jan A.en_US
dc.contributor.authorStott, David J.en_US
dc.contributor.authorSwertz, Morris A.en_US
dc.contributor.authorSwift, Amy J.en_US
dc.contributor.authorTaylor, Kent D.en_US
dc.contributor.authorTayo, Bamidele O.en_US
dc.contributor.authorThorand, Barbaraen_US
dc.contributor.authorThuillier, Dorotheeen_US
dc.contributor.authorTuomilehto, Jaakkoen_US
dc.contributor.authorUitterlinden, Andre G.en_US
dc.contributor.authorVandenput, Liesbethen_US
dc.contributor.authorVohl, Marie-Claudeen_US
dc.contributor.authorVölzke, Henryen_US
dc.contributor.authorVonk, Judith M.en_US
dc.contributor.authorWaeber, Gérarden_US
dc.contributor.authorWaldenberger, Melanieen_US
dc.contributor.authorWestendorp, R. G. J.en_US
dc.contributor.authorWild, Sarahen_US
dc.contributor.authorWillemsen, Gonnekeen_US
dc.contributor.authorWolffenbuttel, Bruce H. R.en_US
dc.contributor.authorWong, Andrewen_US
dc.contributor.authorWright, Alan F.en_US
dc.contributor.authorZhao, Weien_US
dc.contributor.authorZillikens, M Carolaen_US
dc.contributor.authorBaldassarre, Damianoen_US
dc.contributor.authorBalkau, Beverleyen_US
dc.contributor.authorBandinelli, Stefaniaen_US
dc.contributor.authorBöger, Carsten A.en_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorBouchard, Claudeen_US
dc.contributor.authorBruinenberg, Marcelen_US
dc.contributor.authorChasman, Daniel I.en_US
dc.contributor.authorChen, Yii-DerIdaen_US
dc.contributor.authorChines, Peter S.en_US
dc.contributor.authorCooper, Richard S.en_US
dc.contributor.authorCucca, Francescoen_US
dc.contributor.authorCusi, Danieleen_US
dc.contributor.authorFaire, Ulf deen_US
dc.contributor.authorFerrucci, Luigien_US
dc.contributor.authorFranks, Paul W.en_US
dc.contributor.authorFroguel, Philippeen_US
dc.contributor.authorGordon-Larsen, Pennyen_US
dc.contributor.authorGrabe, Hans- Jörgenen_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorHveem, Kristianen_US
dc.contributor.authorJohnson, Andrew D.en_US
dc.contributor.authorWouter Jukema, Jen_US
dc.contributor.authorKardia, Sharon L. R.en_US
dc.contributor.authorKivimaki, Mikaen_US
dc.contributor.authorKooner, Jaspal S.en_US
dc.contributor.authorKuh, Dianaen_US
dc.contributor.authorLaakso, Markkuen_US
dc.contributor.authorLehtimäki, Terhoen_US
dc.contributor.authorMarchand, Loic Leen_US
dc.contributor.authorMärz, Winfrieden_US
dc.contributor.authorMcCarthy, Mark I.en_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorMorris, Andrew P.en_US
dc.contributor.authorOhlsson, Claesen_US
dc.contributor.authorPalmer, Lyle J.en_US
dc.contributor.authorPasterkamp, Gerarden_US
dc.contributor.authorPedersen, Olufen_US
dc.contributor.authorPeters, Annetteen_US
dc.contributor.authorPeters, Ulrikeen_US
dc.contributor.authorPolasek, Ozrenen_US
dc.contributor.authorPsaty, Bruce M.en_US
dc.contributor.authorQi, Luen_US
dc.contributor.authorRauramaa, Raineren_US
dc.contributor.authorSmith, Blair H.en_US
dc.contributor.authorSørensen, Thorkild I. A.en_US
dc.contributor.authorStrauch, Konstantinen_US
dc.contributor.authorTiemeier, Henningen_US
dc.contributor.authorTremoli, Elenaen_US
dc.contributor.authorvan der Harst, Pimen_US
dc.contributor.authorVestergaard, Henriken_US
dc.contributor.authorVollenweider, Peteren_US
dc.contributor.authorWareham, Nicholas J.en_US
dc.contributor.authorWeir, David R.en_US
dc.contributor.authorWhitfield, John B.en_US
dc.contributor.authorWilson, James F.en_US
dc.contributor.authorTyrrell, Jessicaen_US
dc.contributor.authorFrayling, Timothy M.en_US
dc.contributor.authorBarroso, Inêsen_US
dc.contributor.authorBoehnke, Michaelen_US
dc.contributor.authorDeloukas, Panagiotisen_US
dc.contributor.authorFox, Caroline S.en_US
dc.contributor.authorHirschhorn, Joel N.en_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorSpector, Tim D.en_US
dc.contributor.authorStrachan, David P.en_US
dc.contributor.authorvan Duijn, Cornelia M.en_US
dc.contributor.authorHeid, Iris M.en_US
dc.contributor.authorMohlke, Karen L.en_US
dc.contributor.authorMarchini, Jonathanen_US
dc.contributor.authorLoos, Ruth J. F.en_US
dc.contributor.authorKilpeläinen, Tuomas O.en_US
dc.contributor.authorLiu, Ching-Tien_US
dc.contributor.authorBorecki, Ingrid B.en_US
dc.contributor.authorNorth, Kari E.en_US
dc.contributor.authorCupples, L Adrienneen_US
dc.date.accessioned2017-06-15T18:31:40Z
dc.date.issued2017en_US
dc.identifier.citationJustice, A. E., T. W. Winkler, M. F. Feitosa, M. Graff, V. A. Fisher, K. Young, L. Barata, et al. 2017. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8 (1): 14977. doi:10.1038/ncomms14977. http://dx.doi.org/10.1038/ncomms14977.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33030005
dc.description.abstractFew genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/ncomms14977en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414044/pdf/en
dash.licenseLAAen_US
dc.titleGenome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traitsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorAhmad, Shafqaten_US
dc.date.available2017-06-15T18:31:40Z
dc.identifier.doi10.1038/ncomms14977*
dash.authorsorderedfalse
dash.contributor.affiliatedAhmad, Shafqat
dash.contributor.affiliatedHuang, Tao
dash.contributor.affiliatedRidker, Paul
dash.contributor.affiliatedChasman, Daniel
dash.contributor.affiliatedQi, Lu
dash.contributor.affiliatedFranks, Paul
dash.contributor.affiliatedHirschhorn, Joel
dash.contributor.affiliatedHunter, David
dc.identifier.orcid0000-0003-1249-4522


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record