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dc.contributor.authorMozaffarian, Dariush
dc.contributor.authorShi, Peilin
dc.contributor.authorMorris, J. S.
dc.contributor.authorGrandjean, Philippe
dc.contributor.authorSiscovick, D. S.
dc.contributor.authorSpiegelman, Donna Lynn
dc.contributor.authorHu, Frank B.
dc.date.accessioned2017-06-27T14:21:23Z
dc.date.issued2013
dc.identifierQuick submit: 2013-11-08T07:49:46-05:00
dc.identifier.citationMozaffarian, D., P. Shi, J. S. Morris, P. Grandjean, D. S. Siscovick, D. Spiegelman, and F. B. Hu. 2013. “Methylmercury Exposure and Incident Diabetes in U.S. Men and Women in Two Prospective Cohorts.” Diabetes Care 36 (11) (September 11): 3578–3584. doi:10.2337/dc13-0894.en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33087501
dc.description.abstractOBJECTIVE Emerging in vitro and animal evidence suggests that methylmercury could increase type 2 diabetes, but little evidence exists in humans. We aimed to prospectively determine associations of mercury exposure, as assessed by biomarker measurement, with incident diabetes. RESEARCH DESIGN AND METHODS We used neutron activation analysis to measure toenail mercury, an objective biomarker of methylmercury exposure, in 9,267 adults free of diabetes at baseline in two separate U.S. prospective cohorts. Incident diabetes was identified from biennial questionnaires and confirmed by validated supplementary questionnaire using symptoms, diagnostic tests, and medical therapy. Associations of mercury exposure with incident diabetes were assessed using Cox proportional hazards. RESULTS During mean ± SD follow-up of 19.7 ± 7.0 years, 1,010 new cases of diabetes were diagnosed. The 95th percentile of toenail mercury was 1.32 μg/g in men and 0.76 μg/g in women, corresponding to exposures ∼3.5-fold and 2-fold higher than the U.S. Environmental Protection Agency reference dose. In multivariable analyses, toenail mercury concentrations were not associated with higher incidence of diabetes in women, men, or both cohorts combined. Comparing the highest to lowest quintile of exposure, the hazard ratio (95% CI) for incident diabetes was 0.86 (0.66–1.11) in women, 0.69 (0.42–1.15) in men, and 0.77 (0.61–0.98) in the combined cohorts. Findings were similar when more extreme categories (deciles) of mercury were compared, and in analyses stratified by fish or omega-3 consumption, BMI, and age. CONCLUSIONS These findings from two separate large prospective cohorts do not support adverse effects of methylmercury on development of diabetes in men or women at usual levels of exposure seen in these populations.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionof10.2337/dc13-0894en_US
dash.licenseMETA_ONLY
dc.titleMethylmercury Exposure and Incident Diabetes in U.S. Men and Women in Two Prospective Cohortsen_US
dc.typeJournal Articleen_US
dc.date.updated2013-11-08T12:50:53Z
dc.description.versionVersion of Recorden_US
dc.rights.holderMozaffarian D, Shi P, Morris JS, Grandjean P, Siscovick DS, Spiegelman D, Hu FB.
dc.relation.journalDiabetes Careen_US
dash.depositing.authorGrandjean, Philippe
dash.embargo.until10000-01-01
dc.identifier.doi10.2337/dc13-0894*
workflow.legacycommentsGrandjean emailed 2017-03-26 MM meta.darken_US
dash.contributor.affiliatedShi, Peilin
dash.contributor.affiliatedMozaffarian, Dariush
dash.contributor.affiliatedSpiegelman, Donna
dash.contributor.affiliatedGrandjean, Philippe
dash.contributor.affiliatedHu, Frank
dc.identifier.orcid0000-0003-4006-4650
dc.identifier.orcid0000-0003-4046-9658


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