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dc.contributor.authorNeedham, Larry L.
dc.contributor.authorGrandjean, Philippe
dc.contributor.authorHeinzow, Birger
dc.contributor.authorJørgensen, Poul J.
dc.contributor.authorNielsen, Flemming
dc.contributor.authorPatterson, Donald G.
dc.contributor.authorSjödin, Andreas
dc.contributor.authorTurner, Wayman E.
dc.contributor.authorWeihe, Pal
dc.date.accessioned2017-06-27T14:47:53Z
dc.date.issued2011
dc.identifier.citationNeedham, Larry L., Philippe Grandjean, Birger Heinzow, Poul J. Jørgensen, Flemming Nielsen, Donald G. Patterson, Andreas Sjödin, Wayman E. Turner, and Pal Weihe. 2011. “Partition of Environmental Chemicals Between Maternal and Fetal Blood and Tissues.” Environ. Sci. Technol. 45 (3) (February): 1121–1126. doi:10.1021/es1019614.en_US
dc.identifier.issn0013-936Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33087530
dc.description.abstractPassage of environmental chemicals across the placenta has important toxicological consequences, as well as for choosing samples for analysis and for interpreting the results. To obtain systematic data, we collected in 2000 maternal and cord blood, cord tissue, placenta, and milk in connection with births in the Faroe Islands, where exposures to marine contaminants is increased. In 15 sample sets, we measured a total of 87 environmental chemicals, almost all of which were detected both in maternal and fetal tissues. The maternal serum lipid-based concentrations of organohalogen compounds averaged 1.7 times those of cord serum, 2.8 times those of cord tissue and placenta, and 0.7those of milk. For organohalogen compounds detectable in all matrices, a high degree of correlation between concentrations in maternal serum and the other tissues investigated was generally observed (r 2 > 0.5). Greater degree of chlorination resulted in lower transfer from maternal serum into milk. Concentrations of pentachlorbenzene,γ-hexachlorocyclohexane, and several polychlorinated biphenyl congeners with low chlorination were higher in fetal samples and showed poor correlation with maternal levels. Perfluorinated compounds occurred in lower concentrations in cord serum than in maternal serum. Cadmium, lead, mercury, and selenium were all detected in fetal samples, but only mercury showed close correlations among concentrations in different matrices. Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform.en_US
dc.description.sponsorshipOther Research Uniten_US
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofdoi:10.1021/es1019614en_US
dash.licenseOAP
dc.titlePartition of Environmental Chemicals between Maternal and Fetal Blood and Tissuesen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalEnvironmental Science & Technologyen_US
dash.depositing.authorGrandjean, Philippe
dc.date.available2017-06-27T14:47:53Z
dc.identifier.doi10.1021/es1019614*
workflow.legacycommentsauth.collection move to SPH Grandjean emailed 2017-03-26 MM manuscript received 5-21-2017en_US
dash.contributor.affiliatedNielsen, Flemming
dash.contributor.affiliatedWeihe, Pal
dash.contributor.affiliatedGrandjean, Philippe
dc.identifier.orcid0000-0003-4046-9658


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