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dc.contributor.authorGrandjean, Philippe
dc.contributor.authorHenriksen, Jan Erik
dc.contributor.authorChoi, Anna Lai
dc.contributor.authorPetersen, Maria Skaalum
dc.contributor.authorDalgård, Christine
dc.contributor.authorNielsen, Flemming
dc.contributor.authorWeihe, Pal
dc.date.accessioned2017-06-27T14:51:49Z
dc.date.issued2011
dc.identifier.citationGrandjean, Philippe, Jan Erik Henriksen, Anna L. Choi, Maria Skaalum Petersen, Christine Dalgård, Flemming Nielsen, and Pal Weihe. 2011. “Marine Food Pollutants as a Risk Factor for Hypoinsulinemia and Type 2 Diabetes.” Epidemiology 22 (3) (May): 410–417. doi:10.1097/ede.0b013e318212fab9.en_US
dc.identifier.issn1044-3983en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33087555
dc.description.abstractBackground: Some persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after the age of 70. This concern was examined in a cross-sectional study of elderly subjects from a fishing population with elevated contaminant exposures from seafood species high in the food chain. Methods: Clinical examinations of 713 Faroese residents aged 70 –74 years (64% of eligible population) included fasting plasma concentrations of glucose and insulin, and glycosylated hemoglobin. Lifetime exposure to persistent environmental chemicals from pilot whale and other traditional food was estimated from a dietary questionnaire and by analysis of blood samples for polychlorinated biphenyls (PCBs) and related food contaminants. Results: Septuagenarians with type 2 diabetes or impaired fasting glycemia tended to have higher PCB concentrations and higher past intake of traditional foods, especially during childhood and adolescence. In nondiabetic subjects, the fasting insulin concentration decreased by 7% (95% CI 12% to 2%) for each doubling of the PCB concentration after adjustment for sex and body mass index at age 20. Conversely, the fasting glucose concentration increased by 6% (1% to 13%) for each doubling in PCB. Similar associations were seen in subjects without impaired fasting glycemia, while further adjustment for current body mass index and lipid metabolism parameters attenuated some of the associations. Conclusions: Impaired insulin secretion appears to constitute an important part of the type 2 diabetes pathogenesis associated with exposure to persistent lipophilic food contaminants.en_US
dc.description.sponsorshipOther Research Uniten_US
dc.language.isoen_USen_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.relation.isversionofdoi:10.1097/EDE.0b013e318212fab9en_US
dash.licenseOAP
dc.titleMarine Food Pollutants as a Risk Factor for Hypoinsulinemia and Type 2 Diabetesen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalEpidemiologyen_US
dash.depositing.authorGrandjean, Philippe
dc.date.available2017-06-27T14:51:49Z
dc.identifier.doi10.1097/EDE.0b013e318212fab9*
workflow.legacycommentsauth.collection move to SPH Grandjean emailed 2017-03-26 MM Manuscript received 5-21-2017en_US
dash.contributor.affiliatedNielsen, Flemming
dash.contributor.affiliatedChoi, Anna Lai
dash.contributor.affiliatedWeihe, Pal
dash.contributor.affiliatedGrandjean, Philippe
dc.identifier.orcid0000-0003-4046-9658


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