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dc.contributor.authorJulvez, Jordi
dc.contributor.authorDebes, Frodi
dc.contributor.authorWeihe, Pal
dc.contributor.authorChoi, Anna Lai
dc.contributor.authorGrandjean, Philippe
dc.date.accessioned2017-06-27T14:52:50Z
dc.date.issued2011
dc.identifier.citationJulvez, Jordi, Frodi Debes, Pal Weihe, Anna L. Choi, and Philippe Grandjean. 2011. “Thyroid Dysfunction as a Mediator of Organochlorine Neurotoxicity in Preschool Children.” Environmental Health Perspectives 119 (10) (June 30): 1429–1435. doi:10.1289/ehp.1003172. Reproduced with permission from Environmental Health Perspectives.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33087563
dc.description.abstractBackground: Exposure to organochlorine compounds (OCs) can alter thyroid function in humans, and hypothyroidism during early life can adversely affect a child’s neurodevelopment. Objectives: In this study we aimed to assess the relationship between developmental organochlorine exposures and thyroid function and the relationship between thyroid function and subsequent neurodevelopment. Methods: A population-based birth cohort of 182 children was followed annually up to 5.5 years of age. The assessments included OC concentrations in maternal pregnancy serum and milk, clinical thyroid parameters in maternal and cord serum, and subsequent neuropsychological outcomes of the child, along with sociodemographic cofactors. Resin triiodothyronine uptake ratio (T3RU) was also assessed as an estimate of the amount of thyroxine-binding globulin (TBG) sites unsaturated by thyroxine. The T3RU is high in hyperthyroidism and low in hypothyroidism. Results: The findings showed consistent inverse and monotonic associations between organochlorine exposure and T3RU after covariate adjustments. We observed no associations with other thyroid parameters. T3RU was positively associated with improved performance on most of the neuropsychological tests. For other thyroid parameters, the findings were less consistent. Conclusions: The results suggest that OC exposures may decrease the T3RU during early life, which is a proxy measure of the binding capacity of TBG. In addition, minor decreases of the thyroid function may be inversely associated with a child’s neurodevelopment.en_US
dc.description.sponsorshipOther Research Uniten_US
dc.language.isoen_USen_US
dc.publisherEnvironmental Health Perspectivesen_US
dc.relation.isversionofdoi:10.1289/ehp.1003172en_US
dash.licenseLAA
dc.subjectlongitudinal studyen_US
dc.subjectneurodevelopmenten_US
dc.subjectneurotoxicity syndromesen_US
dc.subjectorganochlorine compoundsen_US
dc.subjectprenatal exposure delayed effectsen_US
dc.subjectthyroid hormonesen_US
dc.titleThyroid Dysfunction as a Mediator of Organochlorine Neurotoxicity in Preschool Childrenen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnviron Health Perspecten_US
dash.depositing.authorGrandjean, Philippe
dc.date.available2017-06-27T14:52:50Z
dc.identifier.doi10.1289/ehp.1003172*
dash.contributor.affiliatedChoi, Anna Lai
dash.contributor.affiliatedWeihe, Pal
dash.contributor.affiliatedGrandjean, Philippe
dc.identifier.orcid0000-0003-4046-9658


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