An implantable wireless biosensor for the immediate detection of upper GI bleeding: a new fluorescein-based tool for diagnosis and surveillance (with video)
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Shaikh, Sohail N.
Ryan, Michele B.
Thompson, Christopher C.
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CitationRyou, Marvin, Alex Nemiroski, Dan Azagury, Sohail N. Shaikh, Michele B. Ryan, Robert M. Westervelt, and Christopher C. Thompson. 2011. “An Implantable Wireless Biosensor for the Immediate Detection of Upper GI Bleeding: a New Fluorescein-Based Tool for Diagnosis and Surveillance (with Video).” Gastrointestinal Endoscopy 74 (1) (July): 189–194.e1. doi:10.1016/j.gie.2011.03.1182.
AbstractBackground: Early recurrent hemorrhage after endoscopic intervention for acute upper GI bleeding (UGIB) can approach 20% and leads to increased morbidity and mortality. Little has changed over the past several decades regarding immediate posthemorrhage surveillance, and there has likewise been no significant improvement in outcomes.
Objective: To develop and test an endoscopically implantable wireless biosensor for real-time detection of fluorescein-labeled blood in ex vivo and in vivo porcine models of UGIB.
Setting: Animal laboratory. Design: Benchtop and acute animal studies. Subjects: Five pigs. Interventions: UGIB models were surgically created in living pigs. Biosensors were endoscopically deployed in the stomach using standard endoscopic clips. The ability to detect acute UGIB and estimated blood loss leading to biosensor activation were recorded. Feasibility of wireless data transmission out of the body to an
external computer and cell phone was assessed. Main Outcome Measurements: Technical feasibility and immediate complications. Results: A porcine UGIB model was successfully created. Biosensors were able to detect all acute bleeding events and wirelessly transmit out of the body, and successfully sent an emergency text message to the intended
cell phone in all cases. Average estimated blood loss leading to biosensor activation was 30 mL (10 –75 mL). Limitations: Animal study; small numbers. Conclusions: An endoscopically implantable wireless biosensor successfully detected acute hemorrhage in a porcine UGIB model and sent an emergency cell-phone alert in real time.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33373340
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