Locking the genome: nuclear organization and cell fate

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Locking the genome: nuclear organization and cell fate

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Title: Locking the genome: nuclear organization and cell fate
Author: Meister, Peter; Mango, Susan; Gasser, Susan M

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Citation: Meister, Peter, Susan E Mango, and Susan M Gasser. 2011. Locking the Genome: Nuclear Organization and Cell Fate. Current Opinion in Genetics & Development 21, no. 2: 167–174. doi:10.1016/j.gde.2011.01.023.
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Abstract: The differentiation of pluripotent or totipotent cells into various differentiated cell types is accompanied by a restriction of gene expression patterns, alteration in histone and DNA methylation, and changes in the gross nuclear organization of eu- and heterochromatic domains. Several recent studies have coupled genome-wide mapping of histone modifications with changes in gene expression. Other studies have examined changes in the subnuclear positioning of tissue-specific genes upon transcriptional induction or repression. Here we summarize intriguing correlations of the three phenomena, which suggest that in some cases causal relationships may exist.
Published Version: doi:10.1016/j.gde.2011.01.023
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33439061
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